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- W2323169903 abstract "In ophthalmology, photodynamic therapy (PDT) using hematoporphyrin derivatives has been applied for the treatment of retinoblastoma and uveal melanoma. Recently, PDT is expected for a new treatment modality to ocular neovascularization. In the present study, the efficacy of PDT using a new hydrophilic sensitizer, ATX-S10NaII for the treatment of experimental choroidal neovascularization (CNV) was investigated. CNV was induced in rat fundi by intense argon laser photocoagulation. Fluorescein angiographic study revealed accumulation of ATX-S10 in the CNV from 30 minutes to 4 hours after dye injection. Laser (diode laser, λ=670nm) irradiation applied immediately after dye injection with radiant exposures of 7.4J/cm2, or 2 to 4 hours after dye injection with radiant exposures of 22.0J/cm2, induced occlusion of the CNV without singnificant injury to the retinal vessels. PDT using ATX-S10 using appropriate treatment parameters can occlude CNV. ATX-S10 is supposed to be a promising new generation sensitizer which has rapid elimination from the body and little skin phototoxicity, and it appears to be useful in the treatment of ocular neovascularization." @default.
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- W2323169903 date "1997-01-01" @default.
- W2323169903 modified "2023-10-05" @default.
- W2323169903 title "Application of Photodynamic Therapy in Ophthalmology" @default.
- W2323169903 doi "https://doi.org/10.2530/jslsm1980.18.supplement_117" @default.
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