Matches in SemOpenAlex for { <https://semopenalex.org/work/W2323183075> ?p ?o ?g. }
- W2323183075 abstract "Abstract Recent high throughput sequencing analysis has revealed that the TCRβ repertoire is largely different between CD8 + and CD4 + T cells. Here, we show that the transduction of SIG35α, the public chain-centric HLA-A*02:01(A2)/MART1 27–35 TCRα hemichain, conferred A2/MART1 27–35 reactivity to a substantial subset of both CD8 + and CD4 + T cells regardless of their HLA–A2 positivity. T cells individually reconstituted with SIG35α and different A2/MART1 27–35 TCRβ genes isolated from CD4 + or CD8 + T cells exhibited a wide range of avidity. Surprisingly, approximately half of the A2/MART1 27–35 TCRs derived from CD4 + T cells, but none from CD8 + T cells, were stained by A2/MART1 27–35 monomer and possessed broader cross-reactivity. Our results suggest that the differences in the primary structure of peripheral CD4 + and CD8 + TCRβ repertoire indeed result in the differences in their ability to form extraordinarily high avidity T cells which would otherwise have been deleted by central tolerance." @default.
- W2323183075 created "2016-06-24" @default.
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- W2323183075 date "2016-03-31" @default.
- W2323183075 modified "2023-09-23" @default.
- W2323183075 title "CD4+ and CD8+ TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells" @default.
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- W2323183075 doi "https://doi.org/10.1038/srep23821" @default.
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