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• W2323265909 endingPage "3259" @default.
• W2323265909 startingPage "3251" @default.
• W2323265909 abstract "Abstract A pyrene‐labeled uridine (U Py ) monomer for a pyrrolidinyl peptide nucleic acid with an alternating proline/2‐aminocyclopentanecarboxylic acid backbone (acpcPNA) was synthesized and incorporated into the PNA. The U Py base in acpcPNA could specifically recognize the base A in its complementary DNA strand as determined by thermal denaturation ( T m ) experiments. The fluorescence of the U Py ‐containing single‐stranded acpcPNA was very weak in aqueous buffer. In the presence of a complementary DNA target, the fluorescence was enhanced significantly (2.7–41.9 folds, depending on sequences). The fluorescence enhancement was specific to the pairing between U Py and dA, making the U Py ‐modified acpcPNA useful as a hybridization‐responsive fluorescence probe for DNA‐sequence determination." @default.
• W2323265909 created "2016-06-24" @default.
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• W2323265909 date "2011-09-26" @default.
• W2323265909 modified "2023-10-18" @default.
• W2323265909 title "5-(Pyren-1-yl)uracil as a Base-Discriminating Fluorescent Nucleobase in Pyrrolidinyl Peptide Nucleic Acids" @default.
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• W2323265909 doi "https://doi.org/10.1002/asia.201100490" @default.
• W2323265909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21976408" @default.
• W2323265909 hasPublicationYear "2011" @default.
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