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- W2323317975 endingPage "648" @default.
- W2323317975 startingPage "634" @default.
- W2323317975 abstract "Significance: Iron is the most abundant transition metal in biology and an essential cofactor for many cellular enzymes. Iron homeostasis impairment is also a component of peripheral neuropathies. Recent Advances: During the past years, much effort has been paid to understand the molecular mechanism involved in maintaining systemic iron homeostasis in mammals. This has been stimulated by the evidence that iron dyshomeostasis is an initial cause of several disorders, including genetic and sporadic neurodegenerative disorders. Critical Issues: However, very little has been done to investigate the physiological role of iron in peripheral nervous system (PNS), despite the development of suitable cellular and animal models. Future Directions: To stimulate research on iron metabolism and peripheral neuropathy, we provide a summary of the knowledge on iron homeostasis in the PNS, on its transport across the blood–nerve barrier, its involvement in myelination, and we identify unresolved questions. Furthermore, we comment on the role of iron in iron-related disorder with peripheral component, in demyelinating and metabolic peripheral neuropathies. Antioxid. Redox Signal. 21, 634–648." @default.
- W2323317975 created "2016-06-24" @default.
- W2323317975 creator A5050840680 @default.
- W2323317975 creator A5062270935 @default.
- W2323317975 date "2014-08-01" @default.
- W2323317975 modified "2023-09-27" @default.
- W2323317975 title "Iron Homeostasis in Peripheral Nervous System, Still a Black Box?" @default.
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