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- W2323323089 abstract "A new metal-containing scaffold for the design of protein kinase inhibitors is introduced. The key feature is a 3-(2-pyridyl)-1,8-naphthalimide “pharmacophore chelate ligand”, which is designed to form two hydrogen bonds with the hinge region of the ATP-binding site and is at the same time capable of serving as a stable bidentate ligand through C–H activation at the 4-position of the electron-deficient naphthalene moiety. This C–H activation leads to a reduced demand for coordinating heteroatoms and thus sets the basis for a very efficient three-step synthesis starting from 1,8-naphthalic anhydride. The versatility of this ligand is demonstrated with the discovery of a ruthenium complex that functions as a nanomolar inhibitor for myosin light-chain kinase (MYLK or MLCK)." @default.
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- W2323323089 date "2011-07-18" @default.
- W2323323089 modified "2023-10-10" @default.
- W2323323089 title "Organometallic Pyridylnaphthalimide Complexes as Protein Kinase Inhibitors" @default.
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- W2323323089 doi "https://doi.org/10.1021/om200366r" @default.
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