Matches in SemOpenAlex for { <https://semopenalex.org/work/W2323392012> ?p ?o ?g. }
- W2323392012 endingPage "338" @default.
- W2323392012 startingPage "333" @default.
- W2323392012 abstract "Several studies have shown that symptomatic gallstones are largely a disease of nonsmokers, which raises the possibility that nicotine may protect against the formation of gallstones. To examine the effect of nicotine on the gallbladder, 32 rabbits were allocated to four groups: controls and three treatment groups in which nicotine tartarate at low, medium and high doses was administered subcutaneously via an osmotic minipump. After 14 days’ treatment the gallbladder was removed and measurements made of gallbladder mucin synthesis, bile mucin concentration, bile acid concentration and cholesterol saturation. Serum nicotine concentrations (ng/mL) were (± SE) 0.4±0.1, 3.5±0.4, 8.8±0.8 and 16.2±1.8 in the controls and three treatment groups, respectively. Total bile acid concentration increased significantly in all three treated groups with the greatest increase in the group given low dose nicotine (P<0.001). Cholesterol saturation did not differ significantly in any group but soluble mucin concentration in gallbladder bile was significantly reduced (P=0.013, 95% CI: 16 to 111) with high dose nicotine. Gallbladder mucin synthesis, measured by 3 H-glucosamine incorporation, did not change significantly with nicotine treatment. Subcutaneous nicotine 2.0 mg/kg/day for 14 days significantly reduced the concentration of biliary mucin, which could potentially reduce cholesterol nucleation and subsequent gallstone formation. This may be one of the mechanisms responsible for the relative reduction in gallstone disease among smokers." @default.
- W2323392012 created "2016-06-24" @default.
- W2323392012 creator A5010556700 @default.
- W2323392012 creator A5034953449 @default.
- W2323392012 creator A5042804080 @default.
- W2323392012 creator A5043098981 @default.
- W2323392012 creator A5051224265 @default.
- W2323392012 creator A5055527156 @default.
- W2323392012 creator A5069799622 @default.
- W2323392012 creator A5077861909 @default.
- W2323392012 creator A5083946020 @default.
- W2323392012 creator A5085085960 @default.
- W2323392012 creator A5086608524 @default.
- W2323392012 date "1994-01-01" @default.
- W2323392012 modified "2023-10-18" @default.
- W2323392012 title "Effect of Nicotine on Gallbladder Bile" @default.
- W2323392012 cites W1533289312 @default.
- W2323392012 cites W1649675087 @default.
- W2323392012 cites W1798682103 @default.
- W2323392012 cites W1965397525 @default.
- W2323392012 cites W1965431821 @default.
- W2323392012 cites W1969039489 @default.
- W2323392012 cites W1976488576 @default.
- W2323392012 cites W1978356345 @default.
- W2323392012 cites W1984869042 @default.
- W2323392012 cites W1993729926 @default.
- W2323392012 cites W2008929871 @default.
- W2323392012 cites W2009382804 @default.
- W2323392012 cites W2014572376 @default.
- W2323392012 cites W2026472603 @default.
- W2323392012 cites W2028863228 @default.
- W2323392012 cites W2042170604 @default.
- W2323392012 cites W2044897285 @default.
- W2323392012 cites W2070314106 @default.
- W2323392012 cites W2085117681 @default.
- W2323392012 cites W2094501857 @default.
- W2323392012 cites W2124057260 @default.
- W2323392012 cites W2131101159 @default.
- W2323392012 cites W2144457478 @default.
- W2323392012 cites W2154322083 @default.
- W2323392012 cites W2181636817 @default.
- W2323392012 cites W2270172716 @default.
- W2323392012 cites W2410833011 @default.
- W2323392012 doi "https://doi.org/10.1155/1994/304548" @default.
- W2323392012 hasPublicationYear "1994" @default.
- W2323392012 type Work @default.
- W2323392012 sameAs 2323392012 @default.
- W2323392012 citedByCount "3" @default.
- W2323392012 countsByYear W23233920122020 @default.
- W2323392012 crossrefType "journal-article" @default.
- W2323392012 hasAuthorship W2323392012A5010556700 @default.
- W2323392012 hasAuthorship W2323392012A5034953449 @default.
- W2323392012 hasAuthorship W2323392012A5042804080 @default.
- W2323392012 hasAuthorship W2323392012A5043098981 @default.
- W2323392012 hasAuthorship W2323392012A5051224265 @default.
- W2323392012 hasAuthorship W2323392012A5055527156 @default.
- W2323392012 hasAuthorship W2323392012A5069799622 @default.
- W2323392012 hasAuthorship W2323392012A5077861909 @default.
- W2323392012 hasAuthorship W2323392012A5083946020 @default.
- W2323392012 hasAuthorship W2323392012A5085085960 @default.
- W2323392012 hasAuthorship W2323392012A5086608524 @default.
- W2323392012 hasBestOaLocation W23233920121 @default.
- W2323392012 hasConcept C126322002 @default.
- W2323392012 hasConcept C134018914 @default.
- W2323392012 hasConcept C142724271 @default.
- W2323392012 hasConcept C179264091 @default.
- W2323392012 hasConcept C185592680 @default.
- W2323392012 hasConcept C2777148285 @default.
- W2323392012 hasConcept C2778163477 @default.
- W2323392012 hasConcept C2779388726 @default.
- W2323392012 hasConcept C2779399885 @default.
- W2323392012 hasConcept C2779547902 @default.
- W2323392012 hasConcept C71924100 @default.
- W2323392012 hasConcept C90924648 @default.
- W2323392012 hasConceptScore W2323392012C126322002 @default.
- W2323392012 hasConceptScore W2323392012C134018914 @default.
- W2323392012 hasConceptScore W2323392012C142724271 @default.
- W2323392012 hasConceptScore W2323392012C179264091 @default.
- W2323392012 hasConceptScore W2323392012C185592680 @default.
- W2323392012 hasConceptScore W2323392012C2777148285 @default.
- W2323392012 hasConceptScore W2323392012C2778163477 @default.
- W2323392012 hasConceptScore W2323392012C2779388726 @default.
- W2323392012 hasConceptScore W2323392012C2779399885 @default.
- W2323392012 hasConceptScore W2323392012C2779547902 @default.
- W2323392012 hasConceptScore W2323392012C71924100 @default.
- W2323392012 hasConceptScore W2323392012C90924648 @default.
- W2323392012 hasIssue "5" @default.
- W2323392012 hasLocation W23233920121 @default.
- W2323392012 hasOpenAccess W2323392012 @default.
- W2323392012 hasPrimaryLocation W23233920121 @default.
- W2323392012 hasRelatedWork W1744478083 @default.
- W2323392012 hasRelatedWork W1967860848 @default.
- W2323392012 hasRelatedWork W2015930292 @default.
- W2323392012 hasRelatedWork W2076429703 @default.
- W2323392012 hasRelatedWork W2120667501 @default.
- W2323392012 hasRelatedWork W2141630057 @default.
- W2323392012 hasRelatedWork W2323392012 @default.
- W2323392012 hasRelatedWork W2358168418 @default.