Matches in SemOpenAlex for { <https://semopenalex.org/work/W2323418354> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2323418354 abstract "Glioblastoma multiforme (GBM) is a devastating disease with poor survival rates. Despite years of research, there has been little change in the survival rate or median survival time. HCMV (human cytomegalovirus) was reported in GBM over a decade ago and this finding has the potential to increase our understanding of the disease and it offers a potential tumor specific therapeutic target. Because of this promise, there is a fair amount of time, energy and money being directed towards understanding and utilizing this connection for eventual therapeutic purposes. Despite these ongoing efforts and the time lapsed since the discovery of HCMV in GBM, the association remains controversial. Here we utilized both RNA and DNA sequence data from high-grade gliomas from the Cancer Genome Atlas to assess the veracity of the association between GBM and HCMV (or other infectious agents). Raw sequence reads were aligned to a reference genome containing a human genome (hg19) and a library of virus sequences known to infect humans. Alignments were performed using Spliced Transcripts Alignments to a Reference (STAR). In 56 out of 56 GBM RNA-seq datasets no known viruses were identified. Virome analysis of the DNA-seq datasets demonstrated 40 out of 40 datasets with human herpesvirus 7 ranging from 32 to 10,845 reads. However, upon further analysis, it was determined that these herpesvirus 7 matching reads have low complexity and are consistent with mapping to human telomeric repeats. Therefore, no known viruses were identified at the DNA or RNA levels. This analysis raises the possibility that viruses may not be associated with gliomas as previously reported." @default.
- W2323418354 created "2016-06-24" @default.
- W2323418354 creator A5002551784 @default.
- W2323418354 creator A5034418391 @default.
- W2323418354 creator A5053490217 @default.
- W2323418354 creator A5074051253 @default.
- W2323418354 creator A5077402829 @default.
- W2323418354 creator A5088041804 @default.
- W2323418354 creator A5089449964 @default.
- W2323418354 date "2014-11-01" @default.
- W2323418354 modified "2023-09-26" @default.
- W2323418354 title "GE-33 * A COMPREHENSIVE ASSESSMENT OF VIRAL TRANSCRIPTS IN DNA- AND RNA-SEQ DATASETS FROM HIGH-GRADE GLIOMAS REVEALS NO ASSOCIATION" @default.
- W2323418354 doi "https://doi.org/10.1093/neuonc/nou256.32" @default.
- W2323418354 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4218198" @default.
- W2323418354 hasPublicationYear "2014" @default.
- W2323418354 type Work @default.
- W2323418354 sameAs 2323418354 @default.
- W2323418354 citedByCount "0" @default.
- W2323418354 crossrefType "journal-article" @default.
- W2323418354 hasAuthorship W2323418354A5002551784 @default.
- W2323418354 hasAuthorship W2323418354A5034418391 @default.
- W2323418354 hasAuthorship W2323418354A5053490217 @default.
- W2323418354 hasAuthorship W2323418354A5074051253 @default.
- W2323418354 hasAuthorship W2323418354A5077402829 @default.
- W2323418354 hasAuthorship W2323418354A5088041804 @default.
- W2323418354 hasAuthorship W2323418354A5089449964 @default.
- W2323418354 hasBestOaLocation W23234183541 @default.
- W2323418354 hasConcept C104317684 @default.
- W2323418354 hasConcept C141231307 @default.
- W2323418354 hasConcept C142724271 @default.
- W2323418354 hasConcept C159047783 @default.
- W2323418354 hasConcept C192953774 @default.
- W2323418354 hasConcept C197077220 @default.
- W2323418354 hasConcept C2779134260 @default.
- W2323418354 hasConcept C2779820661 @default.
- W2323418354 hasConcept C51679486 @default.
- W2323418354 hasConcept C54355233 @default.
- W2323418354 hasConcept C552990157 @default.
- W2323418354 hasConcept C67705224 @default.
- W2323418354 hasConcept C70721500 @default.
- W2323418354 hasConcept C71924100 @default.
- W2323418354 hasConcept C86803240 @default.
- W2323418354 hasConceptScore W2323418354C104317684 @default.
- W2323418354 hasConceptScore W2323418354C141231307 @default.
- W2323418354 hasConceptScore W2323418354C142724271 @default.
- W2323418354 hasConceptScore W2323418354C159047783 @default.
- W2323418354 hasConceptScore W2323418354C192953774 @default.
- W2323418354 hasConceptScore W2323418354C197077220 @default.
- W2323418354 hasConceptScore W2323418354C2779134260 @default.
- W2323418354 hasConceptScore W2323418354C2779820661 @default.
- W2323418354 hasConceptScore W2323418354C51679486 @default.
- W2323418354 hasConceptScore W2323418354C54355233 @default.
- W2323418354 hasConceptScore W2323418354C552990157 @default.
- W2323418354 hasConceptScore W2323418354C67705224 @default.
- W2323418354 hasConceptScore W2323418354C70721500 @default.
- W2323418354 hasConceptScore W2323418354C71924100 @default.
- W2323418354 hasConceptScore W2323418354C86803240 @default.
- W2323418354 hasLocation W23234183541 @default.
- W2323418354 hasLocation W23234183542 @default.
- W2323418354 hasOpenAccess W2323418354 @default.
- W2323418354 hasPrimaryLocation W23234183541 @default.
- W2323418354 hasRelatedWork W1975655094 @default.
- W2323418354 hasRelatedWork W1988774162 @default.
- W2323418354 hasRelatedWork W2062327645 @default.
- W2323418354 hasRelatedWork W2069368856 @default.
- W2323418354 hasRelatedWork W2072445382 @default.
- W2323418354 hasRelatedWork W2120584764 @default.
- W2323418354 hasRelatedWork W2124648958 @default.
- W2323418354 hasRelatedWork W2132886470 @default.
- W2323418354 hasRelatedWork W2158441613 @default.
- W2323418354 hasRelatedWork W2167883809 @default.
- W2323418354 hasRelatedWork W2182233285 @default.
- W2323418354 hasRelatedWork W2294783710 @default.
- W2323418354 hasRelatedWork W2539538634 @default.
- W2323418354 hasRelatedWork W2617512476 @default.
- W2323418354 hasRelatedWork W2801588305 @default.
- W2323418354 hasRelatedWork W2953156641 @default.
- W2323418354 hasRelatedWork W2981457875 @default.
- W2323418354 hasRelatedWork W3182836237 @default.
- W2323418354 hasRelatedWork W3210525534 @default.
- W2323418354 hasRelatedWork W911763799 @default.
- W2323418354 isParatext "false" @default.
- W2323418354 isRetracted "false" @default.
- W2323418354 magId "2323418354" @default.
- W2323418354 workType "article" @default.