FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2323418382> ?p ?o ?g. }

• W2323418382 endingPage "40" @default.
• W2323418382 startingPage "33" @default.
• W2323418382 abstract "BACKGROUND The purpose of this study was to evaluate how β-adrenergic receptor inhibition after traumatic brain injury (TBI) alters changes in early cerebral glucose metabolism and motor performance, as well as cerebral cytokine and heat shock protein (HSP) expression. METHODS Mouse cerebral glucose metabolism was measured by microPET fluorodeoxyglucose uptake and converted into standardized uptake values (SUV). Four groups of C57/Bl6 mice (wild type [WT]) were initially evaluated: sham or TBI, followed by tail vein injection of either saline or a nonselective β-adrenergic receptor inhibitor (propranolol, 4 mg/kg). Then motor performance, cerebral cytokine, and HSP70 expression were studied at 12 hours and 24 hours after sham injury or TBI in WT mice treated with saline or propranolol and in β1-adrenergic/β2-adrenergic receptor knockout (BARKO) mice treated with saline. RESULTS Cerebral glucose metabolism was significantly reduced after TBI (mean SUV TBI, 1.63 vs. sham 1.97, p < 0.01) and propranolol attenuated this reduction (mean SUV propranolol, 1.89 vs. saline 1.63, p < 0.01). Both propranolol and BARKO reduced motor deficits at 24 hours after injury, but only BARKO had an effect at 12 hours after injury. TBI WT mice treated with saline performed worse than propranolol mice at 24 hours after injury on rotarod (23 vs. 44 seconds, p < 0.01) and rearing (130 vs. 338 events, p = 0.01) results. At 24 hours after injury, sham BARKO and TBI BARKO mice were similar on rotarod (21 vs. 19 seconds, p = 0.53), ambulatory testing (2,891 vs. 2,274 events, p = 0.14), and rearing (129 vs. 64 events, p = 0.09) results. Interleukin 1β expression was affected by BARKO and propranolol after TBI; attenuation of interleukin 6 and increased HSP70 expression were noted only with BARKO. CONCLUSION β-adrenergic receptor inhibition affects cerebral glucose metabolism, motor performance, as well as cerebral cytokine and HSP expression after TBI. (J Trauma Acute Care Surg. 2012;73: 33–40. Copyright © 2012 by Lippincott Williams & Wilkins)" @default.
• W2323418382 created "2016-06-24" @default.
• W2323418382 creator A5022765894 @default.
• W2323418382 creator A5025405399 @default.
• W2323418382 creator A5033178700 @default.
• W2323418382 creator A5033307071 @default.
• W2323418382 creator A5041380580 @default.
• W2323418382 creator A5052536720 @default.
• W2323418382 creator A5062332723 @default.
• W2323418382 creator A5084943392 @default.
• W2323418382 creator A5086474167 @default.
• W2323418382 creator A5089184781 @default.
• W2323418382 date "2012-07-01" @default.
• W2323418382 modified "2023-09-26" @default.
• W2323418382 title "β-Adrenergic receptor inhibition affects cerebral glucose metabolism, motor performance, and inflammatory response after traumatic brain injury" @default.
• W2323418382 cites W1639095272 @default.
• W2323418382 cites W1966191914 @default.
• W2323418382 cites W1972271649 @default.
• W2323418382 cites W1973968129 @default.
• W2323418382 cites W1977678333 @default.
• W2323418382 cites W1977903609 @default.
• W2323418382 cites W1980398993 @default.
• W2323418382 cites W1984070033 @default.
• W2323418382 cites W1987073290 @default.
• W2323418382 cites W1987877973 @default.
• W2323418382 cites W1989607719 @default.
• W2323418382 cites W1992695208 @default.
• W2323418382 cites W1998462992 @default.
• W2323418382 cites W2008920811 @default.
• W2323418382 cites W2010527958 @default.
• W2323418382 cites W2014362456 @default.
• W2323418382 cites W2020477707 @default.
• W2323418382 cites W2023650135 @default.
• W2323418382 cites W2025457836 @default.
• W2323418382 cites W2041204070 @default.
• W2323418382 cites W2043427017 @default.
• W2323418382 cites W2050590907 @default.
• W2323418382 cites W2053472971 @default.
• W2323418382 cites W2061797107 @default.
• W2323418382 cites W2073466820 @default.
• W2323418382 cites W2082498537 @default.
• W2323418382 cites W2088631845 @default.
• W2323418382 cites W2090114902 @default.
• W2323418382 cites W2107789276 @default.
• W2323418382 cites W2115217673 @default.
• W2323418382 cites W2125696544 @default.
• W2323418382 cites W2127486628 @default.
• W2323418382 cites W2142460451 @default.
• W2323418382 cites W2154288976 @default.
• W2323418382 cites W2171433652 @default.
• W2323418382 cites W4234969553 @default.
• W2323418382 doi "https://doi.org/10.1097/ta.0b013e31825a769b" @default.
• W2323418382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22743370" @default.
• W2323418382 hasPublicationYear "2012" @default.
• W2323418382 type Work @default.
• W2323418382 sameAs 2323418382 @default.
• W2323418382 citedByCount "35" @default.
• W2323418382 countsByYear W23234183822013 @default.
• W2323418382 countsByYear W23234183822014 @default.
• W2323418382 countsByYear W23234183822015 @default.
• W2323418382 countsByYear W23234183822016 @default.
• W2323418382 countsByYear W23234183822017 @default.
• W2323418382 countsByYear W23234183822018 @default.
• W2323418382 countsByYear W23234183822019 @default.
• W2323418382 countsByYear W23234183822020 @default.
• W2323418382 countsByYear W23234183822021 @default.
• W2323418382 countsByYear W23234183822022 @default.
• W2323418382 countsByYear W23234183822023 @default.
• W2323418382 crossrefType "journal-article" @default.
• W2323418382 hasAuthorship W2323418382A5022765894 @default.
• W2323418382 hasAuthorship W2323418382A5025405399 @default.
• W2323418382 hasAuthorship W2323418382A5033178700 @default.
• W2323418382 hasAuthorship W2323418382A5033307071 @default.
• W2323418382 hasAuthorship W2323418382A5041380580 @default.
• W2323418382 hasAuthorship W2323418382A5052536720 @default.
• W2323418382 hasAuthorship W2323418382A5062332723 @default.
• W2323418382 hasAuthorship W2323418382A5084943392 @default.
• W2323418382 hasAuthorship W2323418382A5086474167 @default.
• W2323418382 hasAuthorship W2323418382A5089184781 @default.
• W2323418382 hasConcept C118552586 @default.
• W2323418382 hasConcept C126322002 @default.
• W2323418382 hasConcept C134018914 @default.
• W2323418382 hasConcept C158453852 @default.
• W2323418382 hasConcept C170493617 @default.
• W2323418382 hasConcept C2777397205 @default.
• W2323418382 hasConcept C2778151854 @default.
• W2323418382 hasConcept C2781017439 @default.
• W2323418382 hasConcept C42219234 @default.
• W2323418382 hasConcept C71924100 @default.
• W2323418382 hasConceptScore W2323418382C118552586 @default.
• W2323418382 hasConceptScore W2323418382C126322002 @default.
• W2323418382 hasConceptScore W2323418382C134018914 @default.
• W2323418382 hasConceptScore W2323418382C158453852 @default.
• W2323418382 hasConceptScore W2323418382C170493617 @default.
• W2323418382 hasConceptScore W2323418382C2777397205 @default.
• W2323418382 hasConceptScore W2323418382C2778151854 @default.
• W2323418382 hasConceptScore W2323418382C2781017439 @default.
• W2323418382 hasConceptScore W2323418382C42219234 @default.

• next