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- W2323442714 abstract "Adherens junctions (AJs) and tight junctions (TJs) represent key adhesive structures that regulate the apico-basal polarity and barrier properties of epithelial layers. AJs and TJs readily undergo disassembly and reassembly during normal tissue remodeling and disruption of epithelial barriers in diseases. Such junctional plasticity depends on the orchestrated dynamics of the plasma membrane with its underlying F-actin cytoskeleton, however the interplay between these cellular structures remains poorly understood. Recent studies highlighted the spectrin-adducin-based membrane skeleton as an emerging regulator of AJ and TJ integrity and remodeling. Here we discuss new evidences implicating adducin, spectrin and other membrane skeleton proteins in stabilization of epithelial junctions and regulation of junctional dynamics. Based on the known ability of the membrane skeleton to link cortical actin filaments to the plasma membrane, we hypothesize that the spectrin-adducin network serves as a critical signal and force transducer from the actomyosin cytoskeleton to junctions during remodeling of AJs and TJs." @default.
- W2323442714 created "2016-06-24" @default.
- W2323442714 creator A5042846824 @default.
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- W2323442714 date "2011-07-01" @default.
- W2323442714 modified "2023-10-02" @default.
- W2323442714 title "Spectrin-adducin membrane skeleton" @default.
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- W2323442714 doi "https://doi.org/10.4161/bioa.1.4.17642" @default.
- W2323442714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3210521" @default.
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