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• W2323500463 abstract "84 Background: We have followed a total of 86 patients (pts) [81 had complete data] with AIDS-related neoplasms [non-Hodgkin's lymphoma (NHL) - 39 pts (2 trials); Kaposi's sarcoma (KS) - 31 pts; primary CNS lymphoma (PCL) -5 pts; and Hodgkin's disease (HD) - 6 pts] on five chemotherapy (CT) trials. Methods: Clinical prognostic variables including age, performance status (PS), tumor stage, CD4 count, B symptoms (sxs), prior OI, prior thrush, hemoglobin (Hgb), serum albumin; and 4 QOL indices [FLIC, and 3 summary scales of the BSI: General Severity Index (GSI), Positive Symptom Distress Index (PSDI), and Positive Symptom Total (PST)] were followed prospectively from time of study entry. QOL instruments were given prior to every course of CT (q 3 wks.) Results: Median survival time for each of the groups was NHL 7.0, KS 6.0, HD 6.0 and PCL 1.0 month(s). These 13 parameters and survival time for all 5 trials were compared. Only the PCL group was found to be substantially different from the remaining 4 groups (2 NHL trials, KS, HD) and was therefore dropped from further analysis. Covariates found to be predictive of survival by univariate analysis were: PS (p=.002), stage (p=.02), B sxs (p=.006), CD4 count (p=.0003), prior OI (p=.0001), prior thrush (p=.01), Hgb (p=.0001), albumin (p=.005), FLIC (p=.03) and PSDI (p=.01). These covariates were highly correlated; even adjusting for other covariates, CD4 count was predictive of survival (p=.03). A total of 68 pts completed at least 2 QOL evaluations (average 4.3; range 2-10) and were assessed for change during course of CT. Time from on-study to off-study measurements averaged 118 days. Change in QOL is measured in standardized regression coefficients and the average change observed on the FLIC and PSDI showed no significant change across time (p>.05) while there was significant decline in scores on the GSI, which actually correlates with less distress (p<.05). Conclusions: In pts with AIDS-related neoplasms QOL assessment may be of prognostic value and there is no significant functional deterioration during CT." @default.
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• W2323500463 title "PROSPECTIVE EVALUATION OF CLINICAL PROGNOSTIC FACTORS AND QUALITY OF LIFE (QOL) INDICES USING THE FUNCTIONAL LIVING INDEX-CANCER (FLIC) AND BRIEF SYMPTOM INVENTORY (BSI) IN PATIENTS WITH AIDS-RELATED NEOPLASMS." @default.
• W2323500463 doi "https://doi.org/10.1097/00042560-199804010-00099" @default.
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