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- W2323528833 abstract "In his previous paper the author reached the conclusion, that intralumbarly applied percaine (dibucaine) is rapidly absorbed in almost half the amount of the dose into the circulation; and the circulatory as well as the respiratory depression induced by the lumbar injection of the drug is caused halfly by that part of percaine which escaped toward the blood. The present experiment is to test the rapid absorption of drugs out of the lumbar canal. Methylene blue was injected into the lumbar canal of rabbits. Venous vessels nearby, Vena cava inferior, etc., lungs and heart were found blue colored by the dye within five minutes. Adrenalin applied in the same way increased, if slowly, the blood pressure (Fig. 1). Acetylcholine decreased it when given intralumbarly as rapidly as given intravenously (Fig. 2). The drugs must have been absorbed into the blood and fixed at the peripheral blood vessels, where they are held to display the specific action. In cases of hypodermic injection a thirty or fifty times larger dose of adrenalin or acetylcholine was necessary to elicit the pressor action of the same degree as in cases of lumbar injection. The absorption of adrenalin and acetylcholine from the lumbar canal is achieved incomparably more easily than from the subcutaneous tissue." @default.
- W2323528833 created "2016-06-24" @default.
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- W2323528833 date "1954-01-01" @default.
- W2323528833 modified "2023-09-26" @default.
- W2323528833 title "On the absorption of drugs from the lumbar canal" @default.
- W2323528833 doi "https://doi.org/10.1254/fpj.50.4_478" @default.
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