FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2323590071> ?p ?o ?g. }

• W2323590071 endingPage "283" @default.
• W2323590071 startingPage "277" @default.
• W2323590071 abstract "Abstract The pentavalent rhenium-188 meso-dimercaptosuccinic acid complex 188 Re(V)-DMSA is a beta-emitting analogue of Tc99 m (V)-DMSA, an established tracer that is taken up in a variety of histological different tumors and especially in bone metastases arising from breast and prostate carcinomas. The similar general biodistribution and tumor avidity of 188 Re- and 99m Tc(V)-DMSA therefore suggests the use of the rhenium analog as an agent for therapeutic applications. No-carrier-added 188 Re(V)-DMSA is composed of a mixture of three stereoisomers arising from different orientations of the 4 carboxylate groups of the complex. For therapeutic applications it must be known whether there is a difference in the in-vivo biodistribution and kinetics of the individual stereo isomers. The aim of this study was therefore a) to characterize the chemical stability of each of the 3 stereoisomers with respect to time, temperature and pH and b) to evaluate if there are differences in the in-vivo organ distribution of the pure isomers compared to the isomeric mixture. The in-vitro results revealed for all three individual isomers of 188 Re(V)-DMSA a rather slow (with respect to half-life of Re-188) temperature and pH dependent rate of interconversion which would justify the application of pure isomers. The data obtained from urine samples of rats showed a faster interconversion rate and reached a stable isomer distribution after about six to ten hours, depending on which isomer was injected. However there was no evidence for isomer specific excretion rates. The organ biodistribution patterns of all three isomers were very similar at all times studied (10 min up to 24 hours p.i). The tumor uptake in a rat mammary carcinoma model at 1 hour p.i. did also not show any significant differences. In conclusion the preparation and administration of pure stereoisomers of 188 Re-DMSA is possible, however, in-vivo no significant differences in organ distribution and kinetics were observed which would favour the use of purified stereo isomers over the isomeric mixture of 188 Re(V)-DMSA." @default.
• W2323590071 created "2016-06-24" @default.
• W2323590071 creator A5062927748 @default.
• W2323590071 creator A5065173240 @default.
• W2323590071 creator A5068961348 @default.
• W2323590071 creator A5071483366 @default.
• W2323590071 creator A5074287304 @default.
• W2323590071 creator A5079409881 @default.
• W2323590071 date "2004-04-01" @default.
• W2323590071 modified "2023-10-17" @default.
• W2323590071 title "188Re(V)-DMSA: in-vitro and in-vivo studies on the individual stereo isomers" @default.
• W2323590071 cites W1978247129 @default.
• W2323590071 cites W2005456036 @default.
• W2323590071 cites W2040523156 @default.
• W2323590071 cites W2048322932 @default.
• W2323590071 cites W2050615169 @default.
• W2323590071 cites W2053074081 @default.
• W2323590071 cites W2053988288 @default.
• W2323590071 cites W2059453080 @default.
• W2323590071 cites W2078335674 @default.
• W2323590071 cites W2082161688 @default.
• W2323590071 cites W2498214545 @default.
• W2323590071 cites W4251845255 @default.
• W2323590071 cites W50429148 @default.
• W2323590071 doi "https://doi.org/10.1524/ract.92.4.277.35610" @default.
• W2323590071 hasPublicationYear "2004" @default.
• W2323590071 type Work @default.
• W2323590071 sameAs 2323590071 @default.
• W2323590071 citedByCount "6" @default.
• W2323590071 countsByYear W23235900712012 @default.
• W2323590071 countsByYear W23235900712016 @default.
• W2323590071 countsByYear W23235900712020 @default.
• W2323590071 crossrefType "journal-article" @default.
• W2323590071 hasAuthorship W2323590071A5062927748 @default.
• W2323590071 hasAuthorship W2323590071A5065173240 @default.
• W2323590071 hasAuthorship W2323590071A5068961348 @default.
• W2323590071 hasAuthorship W2323590071A5071483366 @default.
• W2323590071 hasAuthorship W2323590071A5074287304 @default.
• W2323590071 hasAuthorship W2323590071A5079409881 @default.
• W2323590071 hasConcept C110121322 @default.
• W2323590071 hasConcept C112705442 @default.
• W2323590071 hasConcept C121332964 @default.
• W2323590071 hasConcept C134018914 @default.
• W2323590071 hasConcept C134306372 @default.
• W2323590071 hasConcept C138716334 @default.
• W2323590071 hasConcept C148898269 @default.
• W2323590071 hasConcept C150903083 @default.
• W2323590071 hasConcept C159654299 @default.
• W2323590071 hasConcept C176788430 @default.
• W2323590071 hasConcept C177322064 @default.
• W2323590071 hasConcept C178790620 @default.
• W2323590071 hasConcept C179223381 @default.
• W2323590071 hasConcept C185592680 @default.
• W2323590071 hasConcept C202235601 @default.
• W2323590071 hasConcept C202751555 @default.
• W2323590071 hasConcept C203014093 @default.
• W2323590071 hasConcept C207001950 @default.
• W2323590071 hasConcept C2776299442 @default.
• W2323590071 hasConcept C2777807558 @default.
• W2323590071 hasConcept C2780091579 @default.
• W2323590071 hasConcept C33923547 @default.
• W2323590071 hasConcept C3941253 @default.
• W2323590071 hasConcept C505216180 @default.
• W2323590071 hasConcept C55493867 @default.
• W2323590071 hasConcept C62520636 @default.
• W2323590071 hasConcept C71240020 @default.
• W2323590071 hasConcept C71924100 @default.
• W2323590071 hasConcept C86803240 @default.
• W2323590071 hasConcept C98274493 @default.
• W2323590071 hasConceptScore W2323590071C110121322 @default.
• W2323590071 hasConceptScore W2323590071C112705442 @default.
• W2323590071 hasConceptScore W2323590071C121332964 @default.
• W2323590071 hasConceptScore W2323590071C134018914 @default.
• W2323590071 hasConceptScore W2323590071C134306372 @default.
• W2323590071 hasConceptScore W2323590071C138716334 @default.
• W2323590071 hasConceptScore W2323590071C148898269 @default.
• W2323590071 hasConceptScore W2323590071C150903083 @default.
• W2323590071 hasConceptScore W2323590071C159654299 @default.
• W2323590071 hasConceptScore W2323590071C176788430 @default.
• W2323590071 hasConceptScore W2323590071C177322064 @default.
• W2323590071 hasConceptScore W2323590071C178790620 @default.
• W2323590071 hasConceptScore W2323590071C179223381 @default.
• W2323590071 hasConceptScore W2323590071C185592680 @default.
• W2323590071 hasConceptScore W2323590071C202235601 @default.
• W2323590071 hasConceptScore W2323590071C202751555 @default.
• W2323590071 hasConceptScore W2323590071C203014093 @default.
• W2323590071 hasConceptScore W2323590071C207001950 @default.
• W2323590071 hasConceptScore W2323590071C2776299442 @default.
• W2323590071 hasConceptScore W2323590071C2777807558 @default.
• W2323590071 hasConceptScore W2323590071C2780091579 @default.
• W2323590071 hasConceptScore W2323590071C33923547 @default.
• W2323590071 hasConceptScore W2323590071C3941253 @default.
• W2323590071 hasConceptScore W2323590071C505216180 @default.
• W2323590071 hasConceptScore W2323590071C55493867 @default.
• W2323590071 hasConceptScore W2323590071C62520636 @default.
• W2323590071 hasConceptScore W2323590071C71240020 @default.
• W2323590071 hasConceptScore W2323590071C71924100 @default.
• W2323590071 hasConceptScore W2323590071C86803240 @default.

• next