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- W2323599278 abstract "The second position of codon 61 (A to T) in the H-ras gene is a specific mutational site of DMBA-induced hamster cheek pouch squamous cell carcinoma (SCC). We previously reported a high frequency of mutations in the H-ras gene at codon 61 in the late stage of this model of carcinogenesis. However, it is difficult to detect small numbers of genetic abnormalities in a heterogenous population. Mutant allele specific amplification (MASA) is a very sensitive method for detecting micrometastasis in “histologically negative” lymph nodes. We used this method to detect H-ras mutations in premalignant lesions as well as SCCs. Using PCR and direct sequencing, we detected mutations in the H-ras gene in only 30% of advanced cancers but not in early cancer. However, mutations were detected in 15% of dysplastic lesions, 58% of superficial cancer, and 76% of invasive cancers with the use of MASA. These results suggest that 1) MASA is useful for detecting small numbers of genetic abnormalities in a heterogenous population in this model of carcinogenesis and 2) mutations in the H-ras gene occur in the early stage of DMBA-induced hamster cheek pouch carcinogenesis." @default.
- W2323599278 created "2016-06-24" @default.
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- W2323599278 date "1998-01-01" @default.
- W2323599278 modified "2023-09-24" @default.
- W2323599278 title "Application of mutant allele specific amplification(MASA) for detecting H-ras mutations during DMBA-induced hamster cheek pouch carcinogenesis." @default.
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- W2323599278 doi "https://doi.org/10.5794/jjoms.44.925" @default.
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