Matches in SemOpenAlex for { <https://semopenalex.org/work/W2323625212> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2323625212 endingPage "4349" @default.
- W2323625212 startingPage "4340" @default.
- W2323625212 abstract "In order to discriminate the possible racemization mechanisms shown in Chart 1 (for (S)-(-)-1a) for the α-hydroxy ketone moiety (C9-position of the optically active anthracyclinones ((S)-(+)-1a-c), some plausible intermediates ((±)-2 and -3) and their equivalent ((R)-(-)-12) were first synthesized. Thus, the tertiary alcohol ((R)-(-)-12) was prepared from the 1'(S), 2 (R)-diol ((-)-10) according to the reaction scheme shown in Chart 2. The isomeric seven-membered α-hydroxy ketones ((±)-2 and -3) were elaborated from the 1, 4-dihydronaphthalene (13), following the synthetic scheme shown in Charts 3 and 4 based on Dieckmann condensation, dihydroxylation, regioselective enol acetate formation, and oxidation as key steps. By subjecting the plausible intermediates ((±)-2 and -3, 5, and (R)-(-)-12) to the racemization conditions, the facile loss of optical integrity observed for (S)-(+)-1a-c was found to proceed through the ring-expanded seven-membered α-hydroxy ketones ((±)-2 and -3 for (S)-(+)-1a, which might be produced by equilibrium C (Chart 1)." @default.
- W2323625212 created "2016-06-24" @default.
- W2323625212 creator A5007678100 @default.
- W2323625212 creator A5017317111 @default.
- W2323625212 date "1984-01-01" @default.
- W2323625212 modified "2023-10-03" @default.
- W2323625212 title "Elucidation of the racemization mechanism of the .ALPHA.-hydroxy ketone moiety (C9-position) of optically active anthracyclinone derivatives." @default.
- W2323625212 cites W1517180025 @default.
- W2323625212 doi "https://doi.org/10.1248/cpb.32.4340" @default.
- W2323625212 hasPublicationYear "1984" @default.
- W2323625212 type Work @default.
- W2323625212 sameAs 2323625212 @default.
- W2323625212 citedByCount "6" @default.
- W2323625212 countsByYear W23236252122018 @default.
- W2323625212 crossrefType "journal-article" @default.
- W2323625212 hasAuthorship W2323625212A5007678100 @default.
- W2323625212 hasAuthorship W2323625212A5017317111 @default.
- W2323625212 hasBestOaLocation W23236252121 @default.
- W2323625212 hasConcept C146686406 @default.
- W2323625212 hasConcept C155647269 @default.
- W2323625212 hasConcept C161790260 @default.
- W2323625212 hasConcept C178790620 @default.
- W2323625212 hasConcept C185592680 @default.
- W2323625212 hasConcept C2776568683 @default.
- W2323625212 hasConcept C2777495281 @default.
- W2323625212 hasConcept C2777672777 @default.
- W2323625212 hasConcept C2777738585 @default.
- W2323625212 hasConcept C2779515768 @default.
- W2323625212 hasConcept C59759590 @default.
- W2323625212 hasConcept C60002323 @default.
- W2323625212 hasConcept C71240020 @default.
- W2323625212 hasConceptScore W2323625212C146686406 @default.
- W2323625212 hasConceptScore W2323625212C155647269 @default.
- W2323625212 hasConceptScore W2323625212C161790260 @default.
- W2323625212 hasConceptScore W2323625212C178790620 @default.
- W2323625212 hasConceptScore W2323625212C185592680 @default.
- W2323625212 hasConceptScore W2323625212C2776568683 @default.
- W2323625212 hasConceptScore W2323625212C2777495281 @default.
- W2323625212 hasConceptScore W2323625212C2777672777 @default.
- W2323625212 hasConceptScore W2323625212C2777738585 @default.
- W2323625212 hasConceptScore W2323625212C2779515768 @default.
- W2323625212 hasConceptScore W2323625212C59759590 @default.
- W2323625212 hasConceptScore W2323625212C60002323 @default.
- W2323625212 hasConceptScore W2323625212C71240020 @default.
- W2323625212 hasIssue "11" @default.
- W2323625212 hasLocation W23236252121 @default.
- W2323625212 hasOpenAccess W2323625212 @default.
- W2323625212 hasPrimaryLocation W23236252121 @default.
- W2323625212 hasRelatedWork W1585256642 @default.
- W2323625212 hasRelatedWork W1607990770 @default.
- W2323625212 hasRelatedWork W1930341062 @default.
- W2323625212 hasRelatedWork W1975363515 @default.
- W2323625212 hasRelatedWork W1998041998 @default.
- W2323625212 hasRelatedWork W2035824250 @default.
- W2323625212 hasRelatedWork W2053046119 @default.
- W2323625212 hasRelatedWork W2053974077 @default.
- W2323625212 hasRelatedWork W2061671517 @default.
- W2323625212 hasRelatedWork W2062185061 @default.
- W2323625212 hasRelatedWork W2062897035 @default.
- W2323625212 hasRelatedWork W2076060449 @default.
- W2323625212 hasRelatedWork W2078978304 @default.
- W2323625212 hasRelatedWork W2094540478 @default.
- W2323625212 hasRelatedWork W2119400712 @default.
- W2323625212 hasRelatedWork W2127815680 @default.
- W2323625212 hasRelatedWork W2143254272 @default.
- W2323625212 hasRelatedWork W2904482796 @default.
- W2323625212 hasRelatedWork W2950552624 @default.
- W2323625212 hasRelatedWork W354628415 @default.
- W2323625212 hasVolume "32" @default.
- W2323625212 isParatext "false" @default.
- W2323625212 isRetracted "false" @default.
- W2323625212 magId "2323625212" @default.
- W2323625212 workType "article" @default.