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• W2323687961 abstract "BACKGROUND: Early results of postoperative fractionated stereotactic radiotherapy (FSRT) for functional and nonfunctional pituitary adenomas appear promising, but the majority of available evidence draws from small series with insufficient follow-up data to draw meaningful conclusions. OBJECTIVE: To evaluate the long-term outcomes of a large series of patients undergoing FSRT for both functional and nonfunctional pituitary adenomas with the Novalis system (BrainLAB, Heimstetten, Germany). METHODS: Chart data for 75 consecutive patients undergoing FSRT for a pituitary tumor (21 functional and 54 nonfunctional adenomas) at our institution between January 2004 and June 2013 were reviewed. RESULTS: Radiographic progression-free survival was 100% over a mean of 47.8 months of radiographic follow-up (range, 12.0-131.2 months). Hormonal normalization was seen in 69.2% of patients with functional adenomas after FSRT, whereas 30.8% experienced partial hormonal control. Mild, grade I acute adverse effects were observed during radiotherapy treatment in 36 patients (48%), and objective, persistent worsening of vision occurred in a single patient (1.5%) after FSRT. New hormonal deficits were seen in 28.0% of patients after FSRT. Radiographic responses were inversely related to tumor volume. CONCLUSION: FSRT delivers radiographic and functional outcomes similar to those seen with stereotactic radiosurgery and conventional radiotherapy with less resultant toxicity. FSRT is most beneficial for smaller tumors (those <3 cm in diameter). ABBREVIATIONS: EBRT, external beam radiotherapy FSRT, fractionated stereotactic radiotherapy OR, odds ratio PTV, planning target volume SRS, stereotactic radiosurgery" @default.
• W2323687961 created "2016-06-24" @default.
• W2323687961 creator A5037000397 @default.
• W2323687961 creator A5062371635 @default.
• W2323687961 creator A5069998165 @default.
• W2323687961 date "2016-09-01" @default.
• W2323687961 modified "2023-10-18" @default.
• W2323687961 title "Fractionated Stereotactic Radiotherapy for Pituitary Adenomas" @default.
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• W2323687961 doi "https://doi.org/10.1227/neu.0000000000001155" @default.
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