Matches in SemOpenAlex for { <https://semopenalex.org/work/W2323730473> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2323730473 abstract "Background: Premenopausal breast cancer represents Methods: 28 patients with a history of breast cancer or ductal carcinoma in situ (DCIS) who tested negative for a deleterious mutation in the BRCA1 gene were enrolled in the study. Median age was 36.5 (range 28–47). Twenty‐two (78.6%) of the patients had a positive family history of breast and or ovarian cancer, other patients were tested for BRCA mutations on the basis of their young age. Three (10.71%) had DCIS, 2 (7.14%) had stage I, 14 (50%) had stage II, 7 (25%) stage III, and 2 (7.14%) stage IV breast cancer. The estrogen receptor (ER) was positive in 21 (75%) of the samples, progesterone receptor (PR) in 15 (53.56%) and Her‐2/neu was positive (based on IHC scores of 2 or 3 +, or FISH +) in 15 (53.56%) of the patients. Four (14.29%) of the tumors were ER, PR, and Her‐2/neu (triple) negative. At the time of sample collection, 7 patients (25%) were chemotherapy naive and 21 patients (75%) had received chemotherapy. DNA was extracted from PBC then subjected to bisulfite conversion (Invitrogen, MethylCode Bisulfite Conversion kit) and the promoter region was examined using methylation‐specific PCR techniques (−157 to +57, +1 serving as transcription start site). Results: We observed that 3 out of 28 PBCs displayed BRCA1 promoter methylation. Promoter methylation did not correlate with any certain subgroups; however, the numbers of subjects are too small at this point. Conclusions: These preliminary results suggest that 10.7% of sporadic breast cancers have a somatic promoter methylation in the BRCA1 gene. This finding might be important for the development of this test in the assessment of breast cancer risk of women who have no deleterious BRCA1 mutations. Further studies are ongoing to evaluate these promoter methylations in women who are at increased risk for breast cancer. Citation Information: Cancer Prev Res 2010;3(1 Suppl):B50." @default.
- W2323730473 created "2016-06-24" @default.
- W2323730473 creator A5005148722 @default.
- W2323730473 creator A5014713051 @default.
- W2323730473 creator A5015127974 @default.
- W2323730473 creator A5018617106 @default.
- W2323730473 date "2010-01-07" @default.
- W2323730473 modified "2023-09-27" @default.
- W2323730473 title "Abstract B50: Promoter methylation of the BRCA1 gene in young breast cancer patients with no significant family history" @default.
- W2323730473 doi "https://doi.org/10.1158/1940-6207.prev-09-b50" @default.
- W2323730473 hasPublicationYear "2010" @default.
- W2323730473 type Work @default.
- W2323730473 sameAs 2323730473 @default.
- W2323730473 citedByCount "0" @default.
- W2323730473 crossrefType "proceedings-article" @default.
- W2323730473 hasAuthorship W2323730473A5005148722 @default.
- W2323730473 hasAuthorship W2323730473A5014713051 @default.
- W2323730473 hasAuthorship W2323730473A5015127974 @default.
- W2323730473 hasAuthorship W2323730473A5018617106 @default.
- W2323730473 hasConcept C104317684 @default.
- W2323730473 hasConcept C121608353 @default.
- W2323730473 hasConcept C126322002 @default.
- W2323730473 hasConcept C143998085 @default.
- W2323730473 hasConcept C146357865 @default.
- W2323730473 hasConcept C150194340 @default.
- W2323730473 hasConcept C151730666 @default.
- W2323730473 hasConcept C189235521 @default.
- W2323730473 hasConcept C190727270 @default.
- W2323730473 hasConcept C2775959680 @default.
- W2323730473 hasConcept C2780862961 @default.
- W2323730473 hasConcept C2781179581 @default.
- W2323730473 hasConcept C33288867 @default.
- W2323730473 hasConcept C41091548 @default.
- W2323730473 hasConcept C502942594 @default.
- W2323730473 hasConcept C530470458 @default.
- W2323730473 hasConcept C54355233 @default.
- W2323730473 hasConcept C71924100 @default.
- W2323730473 hasConcept C84606932 @default.
- W2323730473 hasConcept C86803240 @default.
- W2323730473 hasConcept C98717036 @default.
- W2323730473 hasConceptScore W2323730473C104317684 @default.
- W2323730473 hasConceptScore W2323730473C121608353 @default.
- W2323730473 hasConceptScore W2323730473C126322002 @default.
- W2323730473 hasConceptScore W2323730473C143998085 @default.
- W2323730473 hasConceptScore W2323730473C146357865 @default.
- W2323730473 hasConceptScore W2323730473C150194340 @default.
- W2323730473 hasConceptScore W2323730473C151730666 @default.
- W2323730473 hasConceptScore W2323730473C189235521 @default.
- W2323730473 hasConceptScore W2323730473C190727270 @default.
- W2323730473 hasConceptScore W2323730473C2775959680 @default.
- W2323730473 hasConceptScore W2323730473C2780862961 @default.
- W2323730473 hasConceptScore W2323730473C2781179581 @default.
- W2323730473 hasConceptScore W2323730473C33288867 @default.
- W2323730473 hasConceptScore W2323730473C41091548 @default.
- W2323730473 hasConceptScore W2323730473C502942594 @default.
- W2323730473 hasConceptScore W2323730473C530470458 @default.
- W2323730473 hasConceptScore W2323730473C54355233 @default.
- W2323730473 hasConceptScore W2323730473C71924100 @default.
- W2323730473 hasConceptScore W2323730473C84606932 @default.
- W2323730473 hasConceptScore W2323730473C86803240 @default.
- W2323730473 hasConceptScore W2323730473C98717036 @default.
- W2323730473 hasLocation W23237304731 @default.
- W2323730473 hasOpenAccess W2323730473 @default.
- W2323730473 hasPrimaryLocation W23237304731 @default.
- W2323730473 hasRelatedWork W149202455 @default.
- W2323730473 hasRelatedWork W1510390179 @default.
- W2323730473 hasRelatedWork W1927170709 @default.
- W2323730473 hasRelatedWork W1972959667 @default.
- W2323730473 hasRelatedWork W1977506104 @default.
- W2323730473 hasRelatedWork W2008766385 @default.
- W2323730473 hasRelatedWork W2011968044 @default.
- W2323730473 hasRelatedWork W2075896055 @default.
- W2323730473 hasRelatedWork W2187352586 @default.
- W2323730473 hasRelatedWork W2319953508 @default.
- W2323730473 hasRelatedWork W2359985045 @default.
- W2323730473 hasRelatedWork W2362830376 @default.
- W2323730473 hasRelatedWork W2372010533 @default.
- W2323730473 hasRelatedWork W2540648301 @default.
- W2323730473 hasRelatedWork W2593950517 @default.
- W2323730473 hasRelatedWork W2765260918 @default.
- W2323730473 hasRelatedWork W2794128359 @default.
- W2323730473 hasRelatedWork W2936388114 @default.
- W2323730473 hasRelatedWork W3197027342 @default.
- W2323730473 hasRelatedWork W3206343988 @default.
- W2323730473 isParatext "false" @default.
- W2323730473 isRetracted "false" @default.
- W2323730473 magId "2323730473" @default.
- W2323730473 workType "article" @default.