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• W2323746162 endingPage "10227" @default.
• W2323746162 startingPage "10210" @default.
• W2323746162 abstract "This study investigated the effect of the biochemical and biophysical properties of the plasma membrane as well as membrane morphology on the susceptibility of human red blood cells to the cholesterol-dependent cytolysin pneumolysin, a key virulence factor of Streptococcus pneumoniae, using single cell studies. We show a correlation between the physical properties of the membrane (bending rigidity and surface and dipole electrostatic potentials) and the susceptibility of red blood cells to pneumolysin-induced hemolysis. We demonstrate that biochemical modifications of the membrane induced by oxidative stress, lipid scrambling, and artificial cell aging modulate the cell response to the toxin. We provide evidence that the diversity of response to pneumolysin in diabetic red blood cells correlates with levels of glycated hemoglobin and that the mechanical properties of the red blood cell plasma membrane are altered in diabetes. Finally, we show that diabetic red blood cells are more resistant to pneumolysin and the related toxin perfringolysin O relative to healthy red blood cells. Taken together, these studies indicate that the diversity of cell response to pneumolysin within a population of human red blood cells is influenced by the biophysical and biochemical status of the plasma membrane and the chemical and/or oxidative stress pre-history of the cell. This study investigated the effect of the biochemical and biophysical properties of the plasma membrane as well as membrane morphology on the susceptibility of human red blood cells to the cholesterol-dependent cytolysin pneumolysin, a key virulence factor of Streptococcus pneumoniae, using single cell studies. We show a correlation between the physical properties of the membrane (bending rigidity and surface and dipole electrostatic potentials) and the susceptibility of red blood cells to pneumolysin-induced hemolysis. We demonstrate that biochemical modifications of the membrane induced by oxidative stress, lipid scrambling, and artificial cell aging modulate the cell response to the toxin. We provide evidence that the diversity of response to pneumolysin in diabetic red blood cells correlates with levels of glycated hemoglobin and that the mechanical properties of the red blood cell plasma membrane are altered in diabetes. Finally, we show that diabetic red blood cells are more resistant to pneumolysin and the related toxin perfringolysin O relative to healthy red blood cells. Taken together, these studies indicate that the diversity of cell response to pneumolysin within a population of human red blood cells is influenced by the biophysical and biochemical status of the plasma membrane and the chemical and/or oxidative stress pre-history of the cell." @default.
• W2323746162 created "2016-06-24" @default.
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• W2323746162 date "2016-05-01" @default.
• W2323746162 modified "2023-10-16" @default.
• W2323746162 title "Red Blood Cell Susceptibility to Pneumolysin" @default.
• W2323746162 cites W112661232 @default.
• W2323746162 cites W136893550 @default.
• W2323746162 cites W1550739985 @default.
• W2323746162 cites W1582012726 @default.
• W2323746162 cites W1660726501 @default.
• W2323746162 cites W1845748453 @default.
• W2323746162 cites W1940650130 @default.
• W2323746162 cites W1963722000 @default.
• W2323746162 cites W1964809614 @default.
• W2323746162 cites W1973863710 @default.
• W2323746162 cites W1977460922 @default.
• W2323746162 cites W1977893502 @default.
• W2323746162 cites W1981054060 @default.
• W2323746162 cites W1984211342 @default.
• W2323746162 cites W1985163107 @default.
• W2323746162 cites W1988155241 @default.
• W2323746162 cites W1989289078 @default.
• W2323746162 cites W1989427916 @default.
• W2323746162 cites W1990167164 @default.
• W2323746162 cites W1993889685 @default.
• W2323746162 cites W1998489383 @default.
• W2323746162 cites W2000714076 @default.
• W2323746162 cites W2000775586 @default.
• W2323746162 cites W2003331118 @default.
• W2323746162 cites W2005220285 @default.
• W2323746162 cites W2005842961 @default.
• W2323746162 cites W2007395394 @default.
• W2323746162 cites W2008772338 @default.
• W2323746162 cites W2009643755 @default.
• W2323746162 cites W2013548323 @default.
• W2323746162 cites W2014218268 @default.
• W2323746162 cites W2015257597 @default.
• W2323746162 cites W2022283741 @default.
• W2323746162 cites W2024827373 @default.
• W2323746162 cites W2026786493 @default.
• W2323746162 cites W2029582401 @default.
• W2323746162 cites W2037081137 @default.
• W2323746162 cites W2038292804 @default.
• W2323746162 cites W2038444883 @default.
• W2323746162 cites W2043544498 @default.
• W2323746162 cites W2043856487 @default.
• W2323746162 cites W2044596656 @default.
• W2323746162 cites W2044861358 @default.
• W2323746162 cites W2045227909 @default.
• W2323746162 cites W2045530413 @default.
• W2323746162 cites W2047558995 @default.
• W2323746162 cites W2048055598 @default.
• W2323746162 cites W2050641067 @default.
• W2323746162 cites W2051150326 @default.
• W2323746162 cites W2055566555 @default.
• W2323746162 cites W2057417107 @default.
• W2323746162 cites W2059918628 @default.
• W2323746162 cites W2061852621 @default.
• W2323746162 cites W2065480048 @default.
• W2323746162 cites W2065968830 @default.
• W2323746162 cites W2066547108 @default.
• W2323746162 cites W2072655618 @default.
• W2323746162 cites W2076273704 @default.
• W2323746162 cites W2080489010 @default.
• W2323746162 cites W2080989088 @default.
• W2323746162 cites W2082056939 @default.
• W2323746162 cites W2083063732 @default.
• W2323746162 cites W2083693202 @default.
• W2323746162 cites W2084202373 @default.
• W2323746162 cites W2084556018 @default.
• W2323746162 cites W2087901582 @default.
• W2323746162 cites W2088363546 @default.
• W2323746162 cites W2088533769 @default.
• W2323746162 cites W2089818502 @default.
• W2323746162 cites W2089934202 @default.
• W2323746162 cites W2090821297 @default.
• W2323746162 cites W2091291019 @default.
• W2323746162 cites W2092484308 @default.
• W2323746162 cites W2092597744 @default.
• W2323746162 cites W2092754535 @default.
• W2323746162 cites W2101716445 @default.
• W2323746162 cites W2105430590 @default.
• W2323746162 cites W2107711016 @default.
• W2323746162 cites W2109610410 @default.
• W2323746162 cites W2117798943 @default.
• W2323746162 cites W2118064574 @default.
• W2323746162 cites W2118781934 @default.

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