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- W2323778396 abstract "We prospectively investigated the lower airway response in boilermakers overhauling an oil-powered boiler. We studied 26 male boilermakers with a mean age (SO) of 43.3 (8.6) yr. Pre-exposure spirome try and methacholine challenge tests were performed before beginning the boiler overhaul; postex posure tests were performed after approximately 4 wk of work on the boiler. Exposure to particulates with an aerodynamic diameter of 10 urn and smaller (PMlO) and respirable vanadium dust were esti mated using daily work diaries and a personal sampling device for respirable particles. Using these estimates, we calculated average and peak exposure between pre- and postexposure tests for each subject. The average PMlOconcentration ranged from 1.44 to 6.69 mg/m 3 , with a mean (SO) of 3.22 (1.42) mg/m 3 ; the average vanadium concentration ranged from 2.2 to 31.3, with a mean (SO) of 12.2 (9.1) J.lg/m 3 • The mean postexposure fall in FEV1 was 140 ± 160 ml (p < 0.01); 24 of 26 subjects had a drop in FEV1. Foreach subject, the adjusted change in FEVI (~FEV1.adj) was calculated by divid ing the change in FEV1 by the average of the pre- and postexposure FEV1 values. The ~FEV1.adj was regressed, controlling age and current smoking status, on average and peak exposure to both PMlO and vanadium. There was a dose-response relationship between average and peak PMlO exposure and ~FEV1.adj: 13 =-0.91 % per rnq/m', p =0.08 and 13 =-1.03% per rnq/m', p =0.03, respectively. However, there was no relationship between ~FEV1.adjand respirable vanadium dust concentration. Furthermore, there was no postexposure change in nonspecific airway responsiveness. In summary, we found a significant fall in FEV1 and a dose-response relationship between ~FEV1 .adj and average and peak PMlOexposure. This across-job drop in FEV1 was not associated with a shift in bronchial re sponsiveness as measured by methacholine. Hauser R, E'reedy S, Hoppin 'A, Christiani DC.Airway obstruction in boilermakers exposed to fuel oil ash: a prospective investigation. AM I RESPIR CRIT CARE MED 1995;152:1478-84." @default.
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- W2323778396 date "1995-01-01" @default.
- W2323778396 modified "2023-09-27" @default.
- W2323778396 title "Airway Obstruction in Boilermakers Exposed to Fuel Oil Ash" @default.
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