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- W2323815616 abstract "Caffeine and chloroquine were administered to pregnant SAFICR mice at doses which were non-teratogenic. Nevertheless, these dose levels enhanced significantly the number of cleft palates produced by 200 rads x-ray. The combination of chloroquine with 200 rads x-ray also resulted in a substantially higher incidence of tail abnormalities. Although the mechanisms of action for most teratogens are undefined, mutagenic damage to DNA has been implicated. We propose a “co-teratogenic” mechanism by which non-teratogenic agents enhance the effectiveness of gene damage in producing fetal abnormalties." @default.
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- W2323815616 date "1983-08-01" @default.
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- W2323815616 title "Validation of the whole-embryo culture method for in vitro tesatogericity testibg" @default.
- W2323815616 doi "https://doi.org/10.1016/0378-4274(83)90455-1" @default.
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