Matches in SemOpenAlex for { <https://semopenalex.org/work/W2323853581> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2323853581 endingPage "127" @default.
- W2323853581 startingPage "124" @default.
- W2323853581 abstract "The azole antimycotics itraconazole and ketoconazole are potent and relatively nonspecific inhibitors of cytochrome P450 enzymes and have a potentially dangerous interaction with midazolam and triazolam. The possible interaction between itraconazole and a short-acting benzodiazepine, temazepam, was investigated in a double-blind, randomized crossover study. Ten healthy volunteers were given placebo or 200 mg itraconazole a day orally for 4 days. The challenge dose of 20 mg of temazepam was ingested on the fourth day, after which plasma samples were collected, and psychomotor performance tests were carried out for 24 h. Despite a statistically significant small increase of the area under the temazepam concentration-time curve, there was no clinically significant interaction, as determined by the psychomotor performance tests. The different metabolic pathways and the lack of significant firstpass metabolism of temazepam explain the great difference in the interaction potential of temazepam compared with midazolam and triazolam. Temazepam, unlike midazolam and triazolam, can be prescribed in usual doses for patients receiving itraconazole and other inhibitors of P450 3A4." @default.
- W2323853581 created "2016-06-24" @default.
- W2323853581 creator A5039947544 @default.
- W2323853581 creator A5089475081 @default.
- W2323853581 creator A5091721438 @default.
- W2323853581 date "1996-04-01" @default.
- W2323853581 modified "2023-09-23" @default.
- W2323853581 title "Lack of Effect of Antimycotic Itraconazole on the Pharmacokinetics or Pharmacodynamics of Temazepam" @default.
- W2323853581 cites W1972930816 @default.
- W2323853581 cites W1982681996 @default.
- W2323853581 cites W1999363883 @default.
- W2323853581 cites W2004576165 @default.
- W2323853581 cites W2017573139 @default.
- W2323853581 cites W2049457605 @default.
- W2323853581 cites W2054040800 @default.
- W2323853581 cites W2060008915 @default.
- W2323853581 cites W2067534618 @default.
- W2323853581 cites W2083882381 @default.
- W2323853581 cites W2089667194 @default.
- W2323853581 cites W2096266931 @default.
- W2323853581 cites W2104093795 @default.
- W2323853581 cites W2105681476 @default.
- W2323853581 cites W2127288395 @default.
- W2323853581 cites W4241401467 @default.
- W2323853581 doi "https://doi.org/10.1097/00007691-199604000-00003" @default.
- W2323853581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8721273" @default.
- W2323853581 hasPublicationYear "1996" @default.
- W2323853581 type Work @default.
- W2323853581 sameAs 2323853581 @default.
- W2323853581 citedByCount "19" @default.
- W2323853581 countsByYear W23238535812012 @default.
- W2323853581 countsByYear W23238535812018 @default.
- W2323853581 crossrefType "journal-article" @default.
- W2323853581 hasAuthorship W2323853581A5039947544 @default.
- W2323853581 hasAuthorship W2323853581A5089475081 @default.
- W2323853581 hasAuthorship W2323853581A5091721438 @default.
- W2323853581 hasConcept C112705442 @default.
- W2323853581 hasConcept C126322002 @default.
- W2323853581 hasConcept C142724271 @default.
- W2323853581 hasConcept C16005928 @default.
- W2323853581 hasConcept C170493617 @default.
- W2323853581 hasConcept C204787440 @default.
- W2323853581 hasConcept C27081682 @default.
- W2323853581 hasConcept C2776814716 @default.
- W2323853581 hasConcept C2777071850 @default.
- W2323853581 hasConcept C2778000748 @default.
- W2323853581 hasConcept C2778173252 @default.
- W2323853581 hasConcept C2779548794 @default.
- W2323853581 hasConcept C2779738154 @default.
- W2323853581 hasConcept C2780315139 @default.
- W2323853581 hasConcept C2780930544 @default.
- W2323853581 hasConcept C2781006864 @default.
- W2323853581 hasConcept C2781064554 @default.
- W2323853581 hasConcept C42219234 @default.
- W2323853581 hasConcept C71924100 @default.
- W2323853581 hasConcept C87813604 @default.
- W2323853581 hasConcept C98274493 @default.
- W2323853581 hasConceptScore W2323853581C112705442 @default.
- W2323853581 hasConceptScore W2323853581C126322002 @default.
- W2323853581 hasConceptScore W2323853581C142724271 @default.
- W2323853581 hasConceptScore W2323853581C16005928 @default.
- W2323853581 hasConceptScore W2323853581C170493617 @default.
- W2323853581 hasConceptScore W2323853581C204787440 @default.
- W2323853581 hasConceptScore W2323853581C27081682 @default.
- W2323853581 hasConceptScore W2323853581C2776814716 @default.
- W2323853581 hasConceptScore W2323853581C2777071850 @default.
- W2323853581 hasConceptScore W2323853581C2778000748 @default.
- W2323853581 hasConceptScore W2323853581C2778173252 @default.
- W2323853581 hasConceptScore W2323853581C2779548794 @default.
- W2323853581 hasConceptScore W2323853581C2779738154 @default.
- W2323853581 hasConceptScore W2323853581C2780315139 @default.
- W2323853581 hasConceptScore W2323853581C2780930544 @default.
- W2323853581 hasConceptScore W2323853581C2781006864 @default.
- W2323853581 hasConceptScore W2323853581C2781064554 @default.
- W2323853581 hasConceptScore W2323853581C42219234 @default.
- W2323853581 hasConceptScore W2323853581C71924100 @default.
- W2323853581 hasConceptScore W2323853581C87813604 @default.
- W2323853581 hasConceptScore W2323853581C98274493 @default.
- W2323853581 hasIssue "2" @default.
- W2323853581 hasLocation W23238535811 @default.
- W2323853581 hasLocation W23238535812 @default.
- W2323853581 hasOpenAccess W2323853581 @default.
- W2323853581 hasPrimaryLocation W23238535811 @default.
- W2323853581 hasRelatedWork W175193621 @default.
- W2323853581 hasRelatedWork W1985758966 @default.
- W2323853581 hasRelatedWork W2004576165 @default.
- W2323853581 hasRelatedWork W2012627536 @default.
- W2323853581 hasRelatedWork W2070384523 @default.
- W2323853581 hasRelatedWork W2103445734 @default.
- W2323853581 hasRelatedWork W2135511048 @default.
- W2323853581 hasRelatedWork W2146164295 @default.
- W2323853581 hasRelatedWork W2323853581 @default.
- W2323853581 hasRelatedWork W6232580 @default.
- W2323853581 hasVolume "18" @default.
- W2323853581 isParatext "false" @default.
- W2323853581 isRetracted "false" @default.
- W2323853581 magId "2323853581" @default.
- W2323853581 workType "article" @default.