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• W2323887287 abstract "Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DCIntroduction:Tongue has a rich nerve supply and is in constant contact with a variety of neurotrophins in the saliva.In tongue/oral cancer, patients suffer from pain that is often more severe than the symptom caused by other cancers, likely due to the stimulation of the nerve endings and/or compression and invasion of sensory nerves. Despite the noticeable neural component in tongue/oral cancer development, high-resolution microscopic observation of the tongue innervation in health and disease has been difficult. This is primarily due to the dispersed neural network in space that cannot be easily portrayed by the standard microtome-based 2-dimensional (2-D) microscopy. The artifact and distortion caused by microtome slicing as well as the challenge of aligning series of microtome slices in precision seriously limit our ability to examine tongue innervation. Method: To overcome the imaging limitation, we prepared transparent mouse tongue specimens by optical clearing (use of immersion solution to reduce random scattering as light travels across media; Fu & Tang, Gastroenterology,139:p1100, 2010 and www.3d-histology.com) and combined vessel painting and3-dimensional (3-D) neurohistology for joint visualization of the tongue tissue architectures. Cardiac perfusion of the fluorescent lectin was used to label the blood vessels. Neuronal markers including PGP9.5, tyrosine hydroxylase, vesicular acetylcholine transporter, and calcitonin gene-related peptide were used as the immunostaining targets of neural tissues. Results: We simultaneously revealed the microstructure, vasculature, and innervation of the normal tongue with μm-level resolution. Examples of 3-D features such as the neurovascular complex at the core of the filiform papilla and the taste bud innervation in the fungiform papilla were used to demonstrate the image quality. In the progression of experimental oral cancer induced by 4-Nitroquinoline-1-oxide, we observed remodeling of the tongue innervation with prominent peri- or intra-lesional nerve fibers, indicating intimate nerve-lesion interactions. Sympathetic, parasympathetic, and sensory nerves were all found associated with the lesion. Conclusion: This tongue innervation imaging method does not require tissue microtome sectioning and provides a useful tool for 3-D presentation and analysis of normal and diseased tongue in an integrated fashion.Citation Format: Tzu-En Hua, Ko-Jiunn Liu, Shiue-Cheng Tang. 3-D imaging and illustration of nerve-lesion association in the mouse tongue of experimental oral cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 716. doi:10.1158/1538-7445.AM2013-716" @default.
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• W2323887287 date "2013-04-15" @default.
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• W2323887287 title "Abstract 716: 3-D imaging and illustration of nerve-lesion association in the mouse tongue of experimental oral cancer." @default.
• W2323887287 doi "https://doi.org/10.1158/1538-7445.am2013-716" @default.
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