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• W2323904145 abstract "Background. In the process of post surgical wound healing locally secreted relays are involved, including also pro-angiogenic factors, factors of hemostasia or fibrinolysis. The function of TAFI in this process is not fully elucidated. The main purpose of this study was to estimate the concentration of thrombin activatable fibrinolysis inhibitor in blood serum of the patient with a surgery wound at each measurement before and after the surgery. Methods. The study included 20 adult patients who received a surgical treatment because of degenerative spine changes. The test consisted in three-time determination of TAFI concentration in blood serum of the patients tested. Conclusions. No statistically significant difference in TAFI concentration in blood serum of the tested patients was observed in each measurement before and after the surgery. TAFI concentration in blood serum of the patients operated on differs significantly compared to the control group in measurement one and three. Introduction The wound healing process is a dynamic and multi-stage process consisting in interaction of numerous biologically active molecules. This process consists of four phases: (1) hemostasis-, protection against local bleeding taking place due to platelet aggregation and activation of the coagulation cascade, (2) inflammatory phase – generating neutrophils to inhibit bacterial invasion, (3) differentiation stage, proliferation of mesenchymal cell migration and (4) tissue remodeling, which closely cooperate with each other and occur in adequate turn (Gosain, & Dipietro, 2004; Guo, & Dipietro, 2010; Hoffman at al., 2006; Laurens, Koolwijk, & De Maat, 2006; Nowak, & Olejek, 2004). Leukocytes, fibroblasts and blood vessels move to the repair space and take part in the tissue regeneration process (Laurens, Koolwijk, & De Maat, 2006). Plasmin as well as other components of the fibrinolytic system actively participate in tissue repair by regulating extracellular matrix remodeling (ECM). Also, TAFI recently discovered protein which is considered to be a link between the clotting process and fibrinolysis, also actively involved in the wound healing process (Boffa, 2003). Decrease of TAFI concentration may lead to impaired wound healing (Hoffman at al., 2006; te Velde at al., 2003). The analysis of the literature suggests that there are only a few studies regarding thrombin activatable fibrinolysis inhibitor (TAFI) function in the process of wound healing which were mainly carried out on mice. The main purpose of this study was the assessment of thrombin activatable fibrinolysis inhibitor (TAFI) in blood serum of the patients with post-surgery wound in each measurement before and after surgery. Detailed research problems are presented in the form of questions: Does TAFI concentration in the blood of operated patients significantly differ compared to the control group? Does TAFI concentration in blood significantly differ in the measurements before and after the surgery? Is there a correlation between each measurement in TAFI concentration? Material and Methods Patients The tests were carried out at Neurosurgical Department and Clinic, Collegium Medicum (CM), Nicolaus Copernicus University (NCU) on the group of 20 patients (9 men and 11 women) at the age of 7-54 lat (average 44±8), subject to surgery treatment because of the degenerative change in the spine. From the studies there were excluded patients who had been diagnosed, apart from the basic unit, another central neural system disease (for example.: proliferative process, vascular malformation as well as diseases with a known impact on the wound healing process, such as accompanying atherosclerosis and its complications, diabetes in pregnancy, cancer, AIDS). Also, there were excluded patients, who had been operated on within the period shorter than 30 days preceding their admission to Neurological and Neurosurgical Nursing Department. The control group consisted of 20 healthy volunteers selected according to sex and age criteria (to the tested group). To the control group there were qualified healthy people who had not been treated by then. Methods The test consisted in three-time venous blood sampling (5 cm of blood) from venipuncture around the bend of the el-" @default.
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• W2323904145 date "2011-10-01" @default.
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• W2323904145 title "Concentration of Thrombin Activatable Fibrinolysis Inhibitor (TAFI) in the Process of Wound Healing After the Neurosurgery: Preliminary Report" @default.
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• W2323904145 doi "https://doi.org/10.15373/2249555x/july2014/135" @default.
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