Matches in SemOpenAlex for { <https://semopenalex.org/work/W2323926712> ?p ?o ?g. }
- W2323926712 endingPage "332" @default.
- W2323926712 startingPage "309" @default.
- W2323926712 abstract "Many viruses encode or subvert cellular microRNAs (miRNAs) to aid in their gene expression, amplification strategies, or pathogenic signatures. miRNAs typically downregulate gene expression by binding to the 3′ untranslated region of their mRNA targets. As a result, target mRNAs are translationally repressed and subsequently deadenylated and degraded. Curiously, hepatitis C virus (HCV), a member of the Flaviviridae family, recruits two molecules of liver-specific microRNA-122 (miR-122) to the 5′ end of its genome. In contrast to the canonical activity of miRNAs, the interactions of miR-122 with the viral genome promote viral RNA accumulation in cultured cells and in animal models of HCV infection. Sequestration of miR-122 results in loss of viral RNA both in cell culture and in the livers of chronic HCV-infected patients. This review discusses the mechanisms by which miR-122 is thought to enhance viral RNA abundance and the consequences of miR-122–HCV interactions. We also describe preliminary findings from phase II clinical trials in patients treated with miR-122 antisense oligonucleotides." @default.
- W2323926712 created "2016-06-24" @default.
- W2323926712 creator A5042896311 @default.
- W2323926712 creator A5049480968 @default.
- W2323926712 date "2016-09-29" @default.
- W2323926712 modified "2023-10-12" @default.
- W2323926712 title "Unraveling the Mysterious Interactions Between Hepatitis C Virus RNA and Liver-Specific MicroRNA-122" @default.
- W2323926712 cites W1873092316 @default.
- W2323926712 cites W1881009043 @default.
- W2323926712 cites W1899499649 @default.
- W2323926712 cites W1964628768 @default.
- W2323926712 cites W1965306643 @default.
- W2323926712 cites W1966153332 @default.
- W2323926712 cites W1967977640 @default.
- W2323926712 cites W1969719961 @default.
- W2323926712 cites W1970626969 @default.
- W2323926712 cites W1973178140 @default.
- W2323926712 cites W1976048929 @default.
- W2323926712 cites W1978016645 @default.
- W2323926712 cites W1978976893 @default.
- W2323926712 cites W1979912768 @default.
- W2323926712 cites W1980269624 @default.
- W2323926712 cites W1981186391 @default.
- W2323926712 cites W1984157841 @default.
- W2323926712 cites W1986208182 @default.
- W2323926712 cites W1986944906 @default.
- W2323926712 cites W1987263725 @default.
- W2323926712 cites W1990214042 @default.
- W2323926712 cites W1992935306 @default.
- W2323926712 cites W1996830006 @default.
- W2323926712 cites W1998581442 @default.
- W2323926712 cites W2001210358 @default.
- W2323926712 cites W2003579943 @default.
- W2323926712 cites W2004864449 @default.
- W2323926712 cites W2005300549 @default.
- W2323926712 cites W2006247279 @default.
- W2323926712 cites W2007914794 @default.
- W2323926712 cites W2008075099 @default.
- W2323926712 cites W2011293614 @default.
- W2323926712 cites W2011848204 @default.
- W2323926712 cites W2013953164 @default.
- W2323926712 cites W2014064723 @default.
- W2323926712 cites W2015336471 @default.
- W2323926712 cites W2016640237 @default.
- W2323926712 cites W2017515700 @default.
- W2323926712 cites W2022832110 @default.
- W2323926712 cites W2022959432 @default.
- W2323926712 cites W2026051181 @default.
- W2323926712 cites W2026531690 @default.
- W2323926712 cites W2026570544 @default.
- W2323926712 cites W2027964187 @default.
- W2323926712 cites W2028068115 @default.
- W2323926712 cites W2029426792 @default.
- W2323926712 cites W2032945651 @default.
- W2323926712 cites W2034241642 @default.
- W2323926712 cites W2037999529 @default.
- W2323926712 cites W2038766179 @default.
- W2323926712 cites W2041825143 @default.
- W2323926712 cites W2042594259 @default.
- W2323926712 cites W2044193462 @default.
- W2323926712 cites W2045402423 @default.
- W2323926712 cites W2046379971 @default.
- W2323926712 cites W2048443894 @default.
- W2323926712 cites W2049115723 @default.
- W2323926712 cites W2049489710 @default.
- W2323926712 cites W2049868101 @default.
- W2323926712 cites W2052480299 @default.
- W2323926712 cites W2053360817 @default.
- W2323926712 cites W2054109341 @default.
- W2323926712 cites W2056726430 @default.
- W2323926712 cites W2061375748 @default.
- W2323926712 cites W2065538503 @default.
- W2323926712 cites W2066035587 @default.
- W2323926712 cites W2067685971 @default.
- W2323926712 cites W2069818879 @default.
- W2323926712 cites W2071596792 @default.
- W2323926712 cites W2072442043 @default.
- W2323926712 cites W2072526326 @default.
- W2323926712 cites W2072636314 @default.
- W2323926712 cites W2072904045 @default.
- W2323926712 cites W2073391234 @default.
- W2323926712 cites W2073718731 @default.
- W2323926712 cites W2075839041 @default.
- W2323926712 cites W2076941967 @default.
- W2323926712 cites W2076984671 @default.
- W2323926712 cites W2078257417 @default.
- W2323926712 cites W2080118328 @default.
- W2323926712 cites W2082213106 @default.
- W2323926712 cites W2082873628 @default.
- W2323926712 cites W2086227770 @default.
- W2323926712 cites W2089462743 @default.
- W2323926712 cites W2091560359 @default.
- W2323926712 cites W2095125813 @default.
- W2323926712 cites W2096744132 @default.
- W2323926712 cites W2098676417 @default.
- W2323926712 cites W2099009731 @default.
- W2323926712 cites W2099383089 @default.
- W2323926712 cites W2099517697 @default.