Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324011154> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2324011154 abstract "Background Novel oral anticoagulants (NOAC) are licensed for the prevention of stroke and systemic embolism in patients with atrial fibrillation (AF). There has been no head-to-head comparison of these agents. The effect of these agents on global thrombotic status, and the relative effects of the different NOACs, is unknown. We aimed to assess the relative and absolute effect of NOACs and warfarin (VKA) on global thrombotic status. Methods We tested the thrombotic profile of 80 patients (61% male, age 72 ± 12 years) with newly diagnosed AF at baseline, and in response to different oral anticoagulant regimens. Patients were anticoagulated with apixaban (n = 20), dabigatran (n = 20), rivaroxaban (n = 20), or warfarin (n = 20). Assessment of thrombotic status was performed using the Global Thrombosis Test (GTT), an automated point-of-care test that assesses both platelet reactivity and endogenous thrombolysis from a native, non-anticoagulated blood sample. The time taken to form an occlusive thrombus under high shear stress (occlusion time, OT), and the time required to restore flow through endogenous thrombolysis (lysis time, LT) were measured at baseline and after being established on stable anticoagulation. Results Oral anticoagulation increased OT (419 ± 122s vs. 584 ± 153s; p = 0.00001), and reduced LT (1922 ± 820s vs. 1615 ± 936s; p = 0.01). Although all anticoagulant regimens prolonged OT, the relative prolongation of the OT from baseline was lower with apixaban than with other NOACs or VKA (apixaban 94 ± 135s, dabigatran 185 ± 149s, rivaroxaban 199 ± 104s, warfarin 184 ± 149s; p = 0.06). Apixaban reduced LT from baseline (2056 ± 568s vs. 1313 ± 885s; p = 0.003), but no reduction in LT was observed with other NOACs or VKA. Patients in the dabigatran group were younger than in other groups (65 ± 11; p = 0.006), but otherwise the groups were well matched for sex, diabetes, hypertension, platelet count, haematocrit and fibrinogen levels, and CHA²DS²VASc score. Conclusions All oral anticoagulants (OACs) prolong OT. Apixaban causes relatively less prolongation of OT than other OACs and also reduces LT. The relatively small increase in OT with apixaban compared to other OACs may explain the observed lower incidence of GI bleeds in large trials with this agent." @default.
- W2324011154 created "2016-06-24" @default.
- W2324011154 creator A5002580360 @default.
- W2324011154 creator A5015718599 @default.
- W2324011154 creator A5031921258 @default.
- W2324011154 creator A5041477606 @default.
- W2324011154 creator A5050771060 @default.
- W2324011154 creator A5067947199 @default.
- W2324011154 creator A5068336562 @default.
- W2324011154 date "2015-06-01" @default.
- W2324011154 modified "2023-10-14" @default.
- W2324011154 title "160 Are there Differential Effects of the Novel Oral Anticoagulants on Global Thrombotic Status?" @default.
- W2324011154 doi "https://doi.org/10.1136/heartjnl-2015-308066.160" @default.
- W2324011154 hasPublicationYear "2015" @default.
- W2324011154 type Work @default.
- W2324011154 sameAs 2324011154 @default.
- W2324011154 citedByCount "0" @default.
- W2324011154 crossrefType "journal-article" @default.
- W2324011154 hasAuthorship W2324011154A5002580360 @default.
- W2324011154 hasAuthorship W2324011154A5015718599 @default.
- W2324011154 hasAuthorship W2324011154A5031921258 @default.
- W2324011154 hasAuthorship W2324011154A5041477606 @default.
- W2324011154 hasAuthorship W2324011154A5050771060 @default.
- W2324011154 hasAuthorship W2324011154A5067947199 @default.
- W2324011154 hasAuthorship W2324011154A5068336562 @default.
- W2324011154 hasConcept C126322002 @default.
- W2324011154 hasConcept C127413603 @default.
- W2324011154 hasConcept C164705383 @default.
- W2324011154 hasConcept C2776301958 @default.
- W2324011154 hasConcept C2778205648 @default.
- W2324011154 hasConcept C2778661090 @default.
- W2324011154 hasConcept C2778810321 @default.
- W2324011154 hasConcept C2779161974 @default.
- W2324011154 hasConcept C2779581417 @default.
- W2324011154 hasConcept C2780638905 @default.
- W2324011154 hasConcept C2780645631 @default.
- W2324011154 hasConcept C2780868729 @default.
- W2324011154 hasConcept C42219234 @default.
- W2324011154 hasConcept C500558357 @default.
- W2324011154 hasConcept C71924100 @default.
- W2324011154 hasConcept C78519656 @default.
- W2324011154 hasConceptScore W2324011154C126322002 @default.
- W2324011154 hasConceptScore W2324011154C127413603 @default.
- W2324011154 hasConceptScore W2324011154C164705383 @default.
- W2324011154 hasConceptScore W2324011154C2776301958 @default.
- W2324011154 hasConceptScore W2324011154C2778205648 @default.
- W2324011154 hasConceptScore W2324011154C2778661090 @default.
- W2324011154 hasConceptScore W2324011154C2778810321 @default.
- W2324011154 hasConceptScore W2324011154C2779161974 @default.
- W2324011154 hasConceptScore W2324011154C2779581417 @default.
- W2324011154 hasConceptScore W2324011154C2780638905 @default.
- W2324011154 hasConceptScore W2324011154C2780645631 @default.
- W2324011154 hasConceptScore W2324011154C2780868729 @default.
- W2324011154 hasConceptScore W2324011154C42219234 @default.
- W2324011154 hasConceptScore W2324011154C500558357 @default.
- W2324011154 hasConceptScore W2324011154C71924100 @default.
- W2324011154 hasConceptScore W2324011154C78519656 @default.
- W2324011154 hasLocation W23240111541 @default.
- W2324011154 hasOpenAccess W2324011154 @default.
- W2324011154 hasPrimaryLocation W23240111541 @default.
- W2324011154 hasRelatedWork W1564690174 @default.
- W2324011154 hasRelatedWork W1926044864 @default.
- W2324011154 hasRelatedWork W1939400597 @default.
- W2324011154 hasRelatedWork W2015947022 @default.
- W2324011154 hasRelatedWork W2222713171 @default.
- W2324011154 hasRelatedWork W2254974595 @default.
- W2324011154 hasRelatedWork W2289707977 @default.
- W2324011154 hasRelatedWork W2329585899 @default.
- W2324011154 hasRelatedWork W2620014056 @default.
- W2324011154 hasRelatedWork W2622276831 @default.
- W2324011154 hasRelatedWork W2775135161 @default.
- W2324011154 hasRelatedWork W2807053921 @default.
- W2324011154 hasRelatedWork W2889573684 @default.
- W2324011154 hasRelatedWork W2908205652 @default.
- W2324011154 hasRelatedWork W2908582202 @default.
- W2324011154 hasRelatedWork W2921334496 @default.
- W2324011154 hasRelatedWork W2991232709 @default.
- W2324011154 hasRelatedWork W3029735202 @default.
- W2324011154 hasRelatedWork W3133574879 @default.
- W2324011154 hasRelatedWork W3176224675 @default.
- W2324011154 isParatext "false" @default.
- W2324011154 isRetracted "false" @default.
- W2324011154 magId "2324011154" @default.
- W2324011154 workType "article" @default.