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- W2324013203 abstract "Whereas previous cross-sectional studies have shown a 1-2 log increase in cell-free HIV-1 RNA viral burden associated with disease progression, recent longitudinal studies reveal a less dynamic association. We addressed this conundrum in a cohort of 17 rapid and 20 slow progressors. Initial levels of serum viral RNA from the rapid progressors were 1 log unit higher than those from the slow progressors. Serum RNA increased by >0.5 log in 10 of the rapid progressors (increase group), but the remaining seven showed a <0.5 log increase (static group). Patients whose serum RNA increased had lower amounts of serum RNA at study entry but not at follow-up compared with the static group. There was a trend toward lower CD4 counts in the static group at follow-up. These data suggest that the timing of specimen evaluation can influence interpretation of viral RNA dynamics in HIV disease." @default.
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- W2324013203 date "1997-03-01" @default.
- W2324013203 modified "2023-09-27" @default.
- W2324013203 title "Dynamics of Cell-free Viral Burden in HIV-1-Infected Patients" @default.
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- W2324013203 doi "https://doi.org/10.1097/00042560-199703010-00007" @default.
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