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- W2324015674 abstract "It is known that glucuronic acid, beside strongly accentuating the function of the liver, has the effect of detoxifying various toxic substances in living organisms by agglomerating and forming so-called agglomerate glucuronic acid. By measuring the time required for coagulation of serum to which glucuronic acid (Glonsan) is added and heat is applied, a marked difference in the length of time was observed between liver diseases, normal subjects and patients of various diseases. The author then utilized this difference for testing the function of the liver and obtained the following results in clinical practice.Experimental Method: 0.5cc of the tested serum was taken in a small test-tube, 0.5cc of glucuronic acid solution containing 50mg of glucuronic acid was added to it and mixed by shaking, placed in a bath preheated to 60°C and the time required for the coagulation of the serum (disappearance of all fluidity) was measured, to estimate the existence or the degree of liver detsturbance. When the time was shorter than 25min. the result was marked negative (-), when between 25 and 30min. quasi-positive (±), when 30-35min. weakly positive (+), when 35-40min. moderately positive (++), when 40-45min. strongly positive (+++) and when more than 50min. extremely positive (++++).Results: All the 20 normal subjects showed negative results, while the 8 acute hepatitis cases, the 6 hepatic cirrhosis cases, the 17 hepatic carcinoma cases and the 2 cases of other liver diseases showed positive G-reaction in every case (100%). The Gros's tests conducted simultaneously showed the rates of positive reaction of 50%, 80%, 87.5% and 100% respectively, while those of Takada's tests were 60%, 100%, 76.4% and 100% per group. In almost all cases of non-hepatic diseases, the results of G-reaction tests were negative, and animal experiments showed that the grade of positiveness rose in parallel with the rise in the degree of the functional disturbance of the liver." @default.
- W2324015674 created "2016-06-24" @default.
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- W2324015674 date "1956-01-01" @default.
- W2324015674 modified "2023-09-25" @default.
- W2324015674 title "A NEW METHOD (G-METHOD) FOR TESTING FUNCTION OF LIVER BY MEANS OF GLUCURONIC ACID" @default.
- W2324015674 doi "https://doi.org/10.2169/naika.45.231" @default.
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