FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324032012> ?p ?o ?g. }

• W2324032012 endingPage "342" @default.
• W2324032012 startingPage "335" @default.
• W2324032012 abstract "In a retrospective study we analysed the levels of the DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) in melanoma metastases in patients receiving dacarbazine (DTIC) either as a single drug or as part of combination chemotherapy regimens, and related the expression levels to the clinical response to treatment. Biopsies of subcutaneous and lymph node metastases obtained before chemotherapy in 65 patients with disseminated malignant melanoma were examined for MGMT protein levels by immunohistochemistry using a monoclonal anti-human MGMT antibody. All patients received chemotherapy with DTIC, given either as a single drug or in combination with vindesine and in some cases cisplatin. DTIC as single agent was given to 44 patients, while 21 received combination chemotherapy. Objective responses to chemotherapy were seen in 12 patients, while 53 patients failed to respond to treatment. The expression of MGMT was determined according to the proportion of antibody-stained tumour cells, using a cut-off level of 50%. In 12 of the patients more than one metastasis was analysed, and in seven of these cases the MGMT expression differed between tumours in the same individual. Among the responders a larger proportion (six out of 12, 50%) had tumours containing less than 50% MGMT-positive tumour cells than among the non-responders (12 out of 53, 23%). These data are consistent with the hypothesis that MGMT contributes to resistance to DTIC-based treatment, although the difference between responders and non-responders with respect to the proportion of MGMT-positive tumour cells was not statistically significant (P = 0.077)." @default.
• W2324032012 created "2016-06-24" @default.
• W2324032012 creator A5022108642 @default.
• W2324032012 creator A5024477189 @default.
• W2324032012 creator A5024889166 @default.
• W2324032012 creator A5063569207 @default.
• W2324032012 creator A5080624696 @default.
• W2324032012 date "2002-08-01" @default.
• W2324032012 modified "2023-10-16" @default.
• W2324032012 title "Analysis of O6-methylguanine-DNA methyltransferase in melanoma tumours in patients treated with dacarbazine-based chemotherapy" @default.
• W2324032012 cites W1918200890 @default.
• W2324032012 cites W1943407880 @default.
• W2324032012 cites W1964030620 @default.
• W2324032012 cites W1966682923 @default.
• W2324032012 cites W1967588280 @default.
• W2324032012 cites W1969106834 @default.
• W2324032012 cites W1976625505 @default.
• W2324032012 cites W1979714492 @default.
• W2324032012 cites W1981174149 @default.
• W2324032012 cites W1982054173 @default.
• W2324032012 cites W1992644438 @default.
• W2324032012 cites W1994362554 @default.
• W2324032012 cites W1999549596 @default.
• W2324032012 cites W2002288639 @default.
• W2324032012 cites W2012732208 @default.
• W2324032012 cites W2024205486 @default.
• W2324032012 cites W2043470252 @default.
• W2324032012 cites W2068306614 @default.
• W2324032012 cites W2073149771 @default.
• W2324032012 cites W2073363401 @default.
• W2324032012 cites W2087212652 @default.
• W2324032012 cites W2088279297 @default.
• W2324032012 cites W2145038462 @default.
• W2324032012 cites W2321252431 @default.
• W2324032012 cites W2328946792 @default.
• W2324032012 cites W2614569084 @default.
• W2324032012 doi "https://doi.org/10.1097/00008390-200208000-00005" @default.
• W2324032012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12170182" @default.
• W2324032012 hasPublicationYear "2002" @default.
• W2324032012 type Work @default.
• W2324032012 sameAs 2324032012 @default.
• W2324032012 citedByCount "23" @default.
• W2324032012 countsByYear W23240320122012 @default.
• W2324032012 countsByYear W23240320122013 @default.
• W2324032012 countsByYear W23240320122014 @default.
• W2324032012 countsByYear W23240320122016 @default.
• W2324032012 countsByYear W23240320122017 @default.
• W2324032012 countsByYear W23240320122018 @default.
• W2324032012 countsByYear W23240320122023 @default.
• W2324032012 crossrefType "journal-article" @default.
• W2324032012 hasAuthorship W2324032012A5022108642 @default.
• W2324032012 hasAuthorship W2324032012A5024477189 @default.
• W2324032012 hasAuthorship W2324032012A5024889166 @default.
• W2324032012 hasAuthorship W2324032012A5063569207 @default.
• W2324032012 hasAuthorship W2324032012A5080624696 @default.
• W2324032012 hasConcept C121608353 @default.
• W2324032012 hasConcept C126322002 @default.
• W2324032012 hasConcept C143998085 @default.
• W2324032012 hasConcept C204232928 @default.
• W2324032012 hasConcept C2776694085 @default.
• W2324032012 hasConcept C2776755627 @default.
• W2324032012 hasConcept C2777389519 @default.
• W2324032012 hasConcept C2777658100 @default.
• W2324032012 hasConcept C2778239845 @default.
• W2324032012 hasConcept C2779013556 @default.
• W2324032012 hasConcept C2779321808 @default.
• W2324032012 hasConcept C2779429289 @default.
• W2324032012 hasConcept C2779527866 @default.
• W2324032012 hasConcept C2780964509 @default.
• W2324032012 hasConcept C33288867 @default.
• W2324032012 hasConcept C502942594 @default.
• W2324032012 hasConcept C54355233 @default.
• W2324032012 hasConcept C552990157 @default.
• W2324032012 hasConcept C71924100 @default.
• W2324032012 hasConcept C86803240 @default.
• W2324032012 hasConcept C91965660 @default.
• W2324032012 hasConceptScore W2324032012C121608353 @default.
• W2324032012 hasConceptScore W2324032012C126322002 @default.
• W2324032012 hasConceptScore W2324032012C143998085 @default.
• W2324032012 hasConceptScore W2324032012C204232928 @default.
• W2324032012 hasConceptScore W2324032012C2776694085 @default.
• W2324032012 hasConceptScore W2324032012C2776755627 @default.
• W2324032012 hasConceptScore W2324032012C2777389519 @default.
• W2324032012 hasConceptScore W2324032012C2777658100 @default.
• W2324032012 hasConceptScore W2324032012C2778239845 @default.
• W2324032012 hasConceptScore W2324032012C2779013556 @default.
• W2324032012 hasConceptScore W2324032012C2779321808 @default.
• W2324032012 hasConceptScore W2324032012C2779429289 @default.
• W2324032012 hasConceptScore W2324032012C2779527866 @default.
• W2324032012 hasConceptScore W2324032012C2780964509 @default.
• W2324032012 hasConceptScore W2324032012C33288867 @default.
• W2324032012 hasConceptScore W2324032012C502942594 @default.
• W2324032012 hasConceptScore W2324032012C54355233 @default.
• W2324032012 hasConceptScore W2324032012C552990157 @default.
• W2324032012 hasConceptScore W2324032012C71924100 @default.
• W2324032012 hasConceptScore W2324032012C86803240 @default.
• W2324032012 hasConceptScore W2324032012C91965660 @default.
• W2324032012 hasIssue "4" @default.

• next