Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324043247> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2324043247 abstract "Dosage recommendations for the initial therapy of congenital hypothyroidism (CH) in newborns vary between 8 microg/kg/d and 10-15 microg/kg/d.To evaluate the practicability of LT4 in liquid form and to define the initial dosage for optimal treatment.Liquid LT4 solution was administered to 28 consecutive newborns with primary CH. We measured TSH, T3, T4, free T3 and free T4 before therapy and during follow-up up to 2 years. After 2 years a standardized developmental test (Griffith) was performed.The median dosage at start of therapy was 12.3 microg LT4/kg/d and decreased to about 5 microg LT4/kg/d after 9 months. The median time of normalization of TSH (< or =6 mU/l) was 2 weeks. In 21 patients, who received a median starting dosage of 12.7 microg LT4/kg (range 9.8-17.1 microg/kg), TSH levels normalized within a median of 1 week. Seven patients receiving only 10.1 microg LT4/kg normalized their TSH only after a median of 2 months.Newborns with CH should normalize their TSH within 1-2 weeks. The initial dose necessary to normalize TSH is not lower when a liquid solution is used. The higher dose used in tablets is not due to inefficient absorption, but rather reflects the increased demand for thyroid hormone in the first weeks of life." @default.
- W2324043247 created "2016-06-24" @default.
- W2324043247 creator A5010923354 @default.
- W2324043247 creator A5033117925 @default.
- W2324043247 creator A5046295614 @default.
- W2324043247 creator A5051258274 @default.
- W2324043247 creator A5076820159 @default.
- W2324043247 date "2004-01-01" @default.
- W2324043247 modified "2023-09-30" @default.
- W2324043247 title "The Use of L-T4 as Liquid Solution Improves the Practicability and Individualized Dosage in Newborns and Infants with Congenital Hypothyroidism" @default.
- W2324043247 cites W1599619427 @default.
- W2324043247 cites W1964342964 @default.
- W2324043247 cites W2024260705 @default.
- W2324043247 cites W2053310599 @default.
- W2324043247 cites W2062462371 @default.
- W2324043247 cites W2067626557 @default.
- W2324043247 cites W2153829103 @default.
- W2324043247 cites W2600307110 @default.
- W2324043247 cites W4206614389 @default.
- W2324043247 doi "https://doi.org/10.1515/jpem.2004.17.7.967" @default.
- W2324043247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15301044" @default.
- W2324043247 hasPublicationYear "2004" @default.
- W2324043247 type Work @default.
- W2324043247 sameAs 2324043247 @default.
- W2324043247 citedByCount "25" @default.
- W2324043247 countsByYear W23240432472012 @default.
- W2324043247 countsByYear W23240432472013 @default.
- W2324043247 countsByYear W23240432472014 @default.
- W2324043247 countsByYear W23240432472015 @default.
- W2324043247 countsByYear W23240432472016 @default.
- W2324043247 countsByYear W23240432472018 @default.
- W2324043247 countsByYear W23240432472019 @default.
- W2324043247 countsByYear W23240432472020 @default.
- W2324043247 countsByYear W23240432472021 @default.
- W2324043247 crossrefType "journal-article" @default.
- W2324043247 hasAuthorship W2324043247A5010923354 @default.
- W2324043247 hasAuthorship W2324043247A5033117925 @default.
- W2324043247 hasAuthorship W2324043247A5046295614 @default.
- W2324043247 hasAuthorship W2324043247A5051258274 @default.
- W2324043247 hasAuthorship W2324043247A5076820159 @default.
- W2324043247 hasConcept C126322002 @default.
- W2324043247 hasConcept C187212893 @default.
- W2324043247 hasConcept C2779258352 @default.
- W2324043247 hasConcept C526584372 @default.
- W2324043247 hasConcept C71924100 @default.
- W2324043247 hasConcept C90924648 @default.
- W2324043247 hasConceptScore W2324043247C126322002 @default.
- W2324043247 hasConceptScore W2324043247C187212893 @default.
- W2324043247 hasConceptScore W2324043247C2779258352 @default.
- W2324043247 hasConceptScore W2324043247C526584372 @default.
- W2324043247 hasConceptScore W2324043247C71924100 @default.
- W2324043247 hasConceptScore W2324043247C90924648 @default.
- W2324043247 hasIssue "7" @default.
- W2324043247 hasLocation W23240432471 @default.
- W2324043247 hasLocation W23240432472 @default.
- W2324043247 hasOpenAccess W2324043247 @default.
- W2324043247 hasPrimaryLocation W23240432471 @default.
- W2324043247 hasRelatedWork W1981968121 @default.
- W2324043247 hasRelatedWork W2002214605 @default.
- W2324043247 hasRelatedWork W2006725740 @default.
- W2324043247 hasRelatedWork W200744748 @default.
- W2324043247 hasRelatedWork W2011960454 @default.
- W2324043247 hasRelatedWork W2060603500 @default.
- W2324043247 hasRelatedWork W2382436825 @default.
- W2324043247 hasRelatedWork W2411536504 @default.
- W2324043247 hasRelatedWork W2748952813 @default.
- W2324043247 hasRelatedWork W2286725550 @default.
- W2324043247 hasVolume "17" @default.
- W2324043247 isParatext "false" @default.
- W2324043247 isRetracted "false" @default.
- W2324043247 magId "2324043247" @default.
- W2324043247 workType "article" @default.