FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324069212> ?p ?o ?g. }

• W2324069212 endingPage "4231" @default.
• W2324069212 startingPage "4220" @default.
• W2324069212 abstract "A metabolic disorder such as Type-2 Diabetes mellitus (T2DM) is a complex disease induced by genetic, environmental, and nutritional factors. The db/db mouse model, bearing a nonfunctional leptin receptor, is widely used to investigate the pathophysiology of T2DM. Fecal extracts of db/db and wild-type littermates were studied to unravel a broad spectrum of new and relevant metabolites related to T2DM as proxies of the interplay of gut microbiome and murine metabolomes. The nontargeted metabolomics approach consists of an integrated analytical concept of high-resolution mass spectrometry FT-ICR-MS, followed by UPLC-TOF-MS/MS experiments. We demonstrate that a metabolic disorder such as T2DM affects the gastrointestinal tract environment, thereby influencing different metabolic pathways and their respective metabolites in diabetic mice. Fatty acids, bile acids concerning cholic and deoxycholic acid, and steroid metabolism were highly discriminative comparing fecal meta-metabolomes of wt and db/db mice. Furthermore, sulfur-(S)-containing metabolites including N-acyl taurines were altered in diabetic mice, enabling us to focus on S-containing metabolites, especially the sulfate and taurine conjugates of bile and fatty acids. Different sulfate containing bile acids including sulfocholic acid, oxocholic acid sulfate, taurocholic acid sulfate, and cyprinol sulfate were significantly altered in diabetic mice. Moreover, we identified 12 new sulfate and taurine conjugates of hydroxylated fatty acids with significant importance in T2DM metabolism in db/db mice." @default.
• W2324069212 created "2016-06-24" @default.
• W2324069212 creator A5002797208 @default.
• W2324069212 creator A5006274955 @default.
• W2324069212 creator A5030677256 @default.
• W2324069212 creator A5052642837 @default.
• W2324069212 creator A5067286029 @default.
• W2324069212 creator A5073762729 @default.
• W2324069212 creator A5089183220 @default.
• W2324069212 creator A5089847134 @default.
• W2324069212 date "2014-09-02" @default.
• W2324069212 modified "2023-10-17" @default.
• W2324069212 title "Importance of Sulfur-Containing Metabolites in Discriminating Fecal Extracts between Normal and Type-2 Diabetic Mice" @default.
• W2324069212 cites W1531635279 @default.
• W2324069212 cites W1547278883 @default.
• W2324069212 cites W1870905795 @default.
• W2324069212 cites W1963514086 @default.
• W2324069212 cites W1963761986 @default.
• W2324069212 cites W1968813633 @default.
• W2324069212 cites W1971606140 @default.
• W2324069212 cites W1972011552 @default.
• W2324069212 cites W1973529232 @default.
• W2324069212 cites W1979905130 @default.
• W2324069212 cites W1982054742 @default.
• W2324069212 cites W1982185581 @default.
• W2324069212 cites W1984031597 @default.
• W2324069212 cites W1987843898 @default.
• W2324069212 cites W1992516918 @default.
• W2324069212 cites W2000482854 @default.
• W2324069212 cites W2005206429 @default.
• W2324069212 cites W2006565594 @default.
• W2324069212 cites W2009759079 @default.
• W2324069212 cites W2017932539 @default.
• W2324069212 cites W2020053653 @default.
• W2324069212 cites W2022631085 @default.
• W2324069212 cites W2029774713 @default.
• W2324069212 cites W2030074543 @default.
• W2324069212 cites W2036720248 @default.
• W2324069212 cites W2039590876 @default.
• W2324069212 cites W2040547956 @default.
• W2324069212 cites W2045074061 @default.
• W2324069212 cites W2048914567 @default.
• W2324069212 cites W2051192888 @default.
• W2324069212 cites W2060940273 @default.
• W2324069212 cites W2069187573 @default.
• W2324069212 cites W2074518678 @default.
• W2324069212 cites W2077593769 @default.
• W2324069212 cites W2078043039 @default.
• W2324069212 cites W2084375915 @default.
• W2324069212 cites W2085370071 @default.
• W2324069212 cites W2087005997 @default.
• W2324069212 cites W2094049581 @default.
• W2324069212 cites W2098900040 @default.
• W2324069212 cites W2099673318 @default.
• W2324069212 cites W2103038927 @default.
• W2324069212 cites W2107961403 @default.
• W2324069212 cites W2114041992 @default.
• W2324069212 cites W2124850376 @default.
• W2324069212 cites W2125318012 @default.
• W2324069212 cites W2125904404 @default.
• W2324069212 cites W2139846209 @default.
• W2324069212 cites W2143584373 @default.
• W2324069212 cites W2144129876 @default.
• W2324069212 cites W2145265944 @default.
• W2324069212 cites W2155666326 @default.
• W2324069212 cites W2155671521 @default.
• W2324069212 cites W2163351284 @default.
• W2324069212 cites W2167315466 @default.
• W2324069212 cites W2169838204 @default.
• W2324069212 cites W4211102462 @default.
• W2324069212 cites W4211163242 @default.
• W2324069212 doi "https://doi.org/10.1021/pr500046b" @default.
• W2324069212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24991707" @default.
• W2324069212 hasPublicationYear "2014" @default.
• W2324069212 type Work @default.
• W2324069212 sameAs 2324069212 @default.
• W2324069212 citedByCount "23" @default.
• W2324069212 countsByYear W23240692122015 @default.
• W2324069212 countsByYear W23240692122016 @default.
• W2324069212 countsByYear W23240692122017 @default.
• W2324069212 countsByYear W23240692122018 @default.
• W2324069212 countsByYear W23240692122019 @default.
• W2324069212 countsByYear W23240692122020 @default.
• W2324069212 countsByYear W23240692122021 @default.
• W2324069212 countsByYear W23240692122022 @default.
• W2324069212 crossrefType "journal-article" @default.
• W2324069212 hasAuthorship W2324069212A5002797208 @default.
• W2324069212 hasAuthorship W2324069212A5006274955 @default.
• W2324069212 hasAuthorship W2324069212A5030677256 @default.
• W2324069212 hasAuthorship W2324069212A5052642837 @default.
• W2324069212 hasAuthorship W2324069212A5067286029 @default.
• W2324069212 hasAuthorship W2324069212A5073762729 @default.
• W2324069212 hasAuthorship W2324069212A5089183220 @default.
• W2324069212 hasAuthorship W2324069212A5089847134 @default.
• W2324069212 hasConcept C134018914 @default.
• W2324069212 hasConcept C178790620 @default.
• W2324069212 hasConcept C185592680 @default.
• W2324069212 hasConcept C192989942 @default.

• next