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• W2324086720 abstract "This chapter focuses on transition metals. All transition metal cations are toxic-those that are essential for Escherichia coli and belong to the first transition period of the periodic system of the element and also the toxic-only metals with higher atomic numbers. Common themes are visible in the metabolism of these ions. First, there is transport. High-rate but low-affinity uptake systems provide a variety of cations and anions to the cells. Control of the respective systems seems to be mainly through regulation of transport activity (flux control), with control of gene expression playing only a minor role. If these systems do not provide sufficient amounts of a needed ion to the cell, genes for ATP-hydrolyzing high-affinity but low-rate uptake systems are induced, e.g., ABC transport systems or P-type ATPases. On the other hand, if the amount of an ion is in surplus, genes for efflux systems are induced. By combining different kinds of uptake and efflux systems with regulation at the levels of gene expression and transport activity, the concentration of a single ion in the cytoplasm and the composition of the cellular ion bouquet can be rapidly adjusted and carefully controlled. The toxicity threshold of an ion is defined by its ability to produce radicals (copper, iron, chromate), to bind to sulfide and thiol groups (copper, zinc, all cations of the second and third transition period), or to interfere with the metabolism of other ions. Iron poses an exceptional metabolic problem due its metabolic importance and the low solubility of Fe(III) compounds, combined with the ability to cause dangerous Fenton reactions. This dilemma for the cells led to the evolution of sophisticated multi-channel iron uptake and storage pathways to prevent the occurrence of unbound iron in the cytoplasm. Toxic metals like Cd2+ bind to thiols and sulfide, preventing assembly of iron complexes and releasing the metal from iron-sulfur clusters. In the unique case of mercury, the cation can be reduced to the volatile metallic form. Interference of nickel and cobalt with iron is prevented by the low abundance of these metals in the cytoplasm and their sequestration by metal chaperones, in the case of nickel, or by B12 and its derivatives, in the case of cobalt. The most dangerous metal, copper, catalyzes Fenton-like reactions, binds to thiol groups, and interferes with iron metabolism. E. coli solves this problem probably by preventing copper uptake, combined with rapid efflux if the metal happens to enter the cytoplasm." @default.
• W2324086720 created "2016-06-24" @default.
• W2324086720 creator A5011684428 @default.
• W2324086720 creator A5025032843 @default.
• W2324086720 date "2009-02-13" @default.
• W2324086720 modified "2023-09-27" @default.
• W2324086720 title "Transition Metal Homeostasis" @default.
• W2324086720 cites W102956853 @default.
• W2324086720 cites W11821416 @default.
• W2324086720 cites W120043648 @default.
• W2324086720 cites W136082683 @default.
• W2324086720 cites W1480296056 @default.
• W2324086720 cites W1489896588 @default.
• W2324086720 cites W1492501257 @default.
• W2324086720 cites W1492516958 @default.
• W2324086720 cites W1493787054 @default.
• W2324086720 cites W1502572922 @default.
• W2324086720 cites W1503817775 @default.
• W2324086720 cites W1505328953 @default.
• W2324086720 cites W1513015502 @default.
• W2324086720 cites W1513163868 @default.
• W2324086720 cites W1514186391 @default.
• W2324086720 cites W1515791329 @default.
• W2324086720 cites W1515936592 @default.
• W2324086720 cites W1518305194 @default.
• W2324086720 cites W1523838071 @default.
• W2324086720 cites W1527408421 @default.
• W2324086720 cites W1531528962 @default.
• W2324086720 cites W1537919308 @default.
• W2324086720 cites W1538932254 @default.
• W2324086720 cites W1542556271 @default.
• W2324086720 cites W1546794253 @default.
• W2324086720 cites W1547438680 @default.
• W2324086720 cites W1548845294 @default.
• W2324086720 cites W1555469750 @default.
• W2324086720 cites W1560812415 @default.
• W2324086720 cites W1562302722 @default.
• W2324086720 cites W1563527550 @default.
• W2324086720 cites W1568431853 @default.
• W2324086720 cites W1569302748 @default.
• W2324086720 cites W1571275312 @default.
• W2324086720 cites W1571768010 @default.
• W2324086720 cites W1574579188 @default.
• W2324086720 cites W1576292254 @default.
• W2324086720 cites W1579043425 @default.
• W2324086720 cites W1581392276 @default.
• W2324086720 cites W1587060900 @default.
• W2324086720 cites W1588205173 @default.
• W2324086720 cites W1594203759 @default.
• W2324086720 cites W1596624275 @default.
• W2324086720 cites W1599282595 @default.
• W2324086720 cites W1603707660 @default.
• W2324086720 cites W1606573610 @default.
• W2324086720 cites W1618726667 @default.
• W2324086720 cites W1626847006 @default.
• W2324086720 cites W1627905226 @default.
• W2324086720 cites W1629869967 @default.
• W2324086720 cites W1632119174 @default.
• W2324086720 cites W1658844382 @default.
• W2324086720 cites W165977401 @default.
• W2324086720 cites W1662179012 @default.
• W2324086720 cites W1670305756 @default.
• W2324086720 cites W1760095190 @default.
• W2324086720 cites W1768948929 @default.
• W2324086720 cites W1771723362 @default.
• W2324086720 cites W1792710261 @default.
• W2324086720 cites W1821933068 @default.
• W2324086720 cites W1833087286 @default.
• W2324086720 cites W1836520876 @default.
• W2324086720 cites W1837905731 @default.
• W2324086720 cites W1843827618 @default.
• W2324086720 cites W1898511340 @default.
• W2324086720 cites W1901972977 @default.
• W2324086720 cites W1907426129 @default.
• W2324086720 cites W1917523783 @default.
• W2324086720 cites W1928742612 @default.
• W2324086720 cites W1929504943 @default.
• W2324086720 cites W1947432306 @default.
• W2324086720 cites W1960215150 @default.
• W2324086720 cites W1964426240 @default.
• W2324086720 cites W1964668202 @default.
• W2324086720 cites W1965135816 @default.
• W2324086720 cites W1965865579 @default.
• W2324086720 cites W1965909772 @default.
• W2324086720 cites W1967245994 @default.
• W2324086720 cites W1967596159 @default.
• W2324086720 cites W1967946076 @default.
• W2324086720 cites W1968185653 @default.
• W2324086720 cites W1969529960 @default.
• W2324086720 cites W1970199039 @default.
• W2324086720 cites W1970477208 @default.
• W2324086720 cites W1971251862 @default.
• W2324086720 cites W1971706626 @default.
• W2324086720 cites W1972144893 @default.
• W2324086720 cites W1972656394 @default.
• W2324086720 cites W1972827240 @default.
• W2324086720 cites W1973345591 @default.
• W2324086720 cites W1973453360 @default.
• W2324086720 cites W1974113406 @default.
• W2324086720 cites W1974939001 @default.

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