Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324110651> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2324110651 abstract "Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FLGlobal DNA hypomethylation and concomitant site-specific gene hypermethylation are among the most common molecular alterations in human neoplasia. Although site-specific DNA hypermethylation has been shown to be associated with the development of various tumors accompanied by transcriptional silencing of target genes, the functional significance of global DNA hypomethylation in tumorigenesis remains unclear. Previous studies have revealed that a genetic reduction of the DNA methylation levels leads to opposing effects on tumor development, depending on the tumor cell type and the stage of tumorigenesis. In the present study, we investigated the effect of DNA hypomethylation on gastric carcinogenesis in mice. DNA methyltransferase 1 (Dnmt1) hypomorphic mice, which showed that Dnmt1 hypomorphic alleles induced global DNA hypomethylation in the gastric mucosa, were used in this study. The genetic reduction of DNA methylation levels suppressed the incidence, number and size of gastric tumors in two different mouse models for gastric tumorigenesis: the N-methyl-N-nitrosourea (MNU)-induced model and the Apc (Min/+) mouse model that spontaneously develops gastric tumors with aging. Histological analyses revealed DNA hypomethylation to completely inhibit the development of invasive gastric tumors. In the MNU model, DNA hypomethylation reduced the persistent increase in the cell proliferative activity in the non-cancerous gastric mucosa exposed to MNU. However, the aberrant site-specific methylations were not found in MNU-induced mouse gastric tumors unlike in the case of human gastric tumors, thus indicating that the pattern of the site-specific aberrant methylations in mouse gastric tumors is distinctly different from that in human gastric cancers. Taken together, these findings indicate that the reduction of DNA methylation levels suppresses gastric carcinogenesis and suggest that DNA methylation is closely associated with gastric tumorigenesis.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2796. doi:10.1158/1538-7445.AM2011-2796" @default.
- W2324110651 created "2016-06-24" @default.
- W2324110651 creator A5012448345 @default.
- W2324110651 creator A5015424874 @default.
- W2324110651 creator A5017623051 @default.
- W2324110651 creator A5056300991 @default.
- W2324110651 date "2011-04-15" @default.
- W2324110651 modified "2023-09-27" @default.
- W2324110651 title "Abstract 2796: Suppressive effect of DNA hypomethylation on gastric carcinogenesis" @default.
- W2324110651 doi "https://doi.org/10.1158/1538-7445.am2011-2796" @default.
- W2324110651 hasPublicationYear "2011" @default.
- W2324110651 type Work @default.
- W2324110651 sameAs 2324110651 @default.
- W2324110651 citedByCount "0" @default.
- W2324110651 crossrefType "proceedings-article" @default.
- W2324110651 hasAuthorship W2324110651A5012448345 @default.
- W2324110651 hasAuthorship W2324110651A5015424874 @default.
- W2324110651 hasAuthorship W2324110651A5017623051 @default.
- W2324110651 hasAuthorship W2324110651A5056300991 @default.
- W2324110651 hasConcept C104317684 @default.
- W2324110651 hasConcept C121608353 @default.
- W2324110651 hasConcept C150194340 @default.
- W2324110651 hasConcept C153911025 @default.
- W2324110651 hasConcept C175211621 @default.
- W2324110651 hasConcept C190727270 @default.
- W2324110651 hasConcept C2779422922 @default.
- W2324110651 hasConcept C2779979206 @default.
- W2324110651 hasConcept C2781443798 @default.
- W2324110651 hasConcept C33288867 @default.
- W2324110651 hasConcept C41091548 @default.
- W2324110651 hasConcept C502942594 @default.
- W2324110651 hasConcept C54355233 @default.
- W2324110651 hasConcept C552990157 @default.
- W2324110651 hasConcept C55493867 @default.
- W2324110651 hasConcept C555283112 @default.
- W2324110651 hasConcept C86803240 @default.
- W2324110651 hasConcept C91965660 @default.
- W2324110651 hasConceptScore W2324110651C104317684 @default.
- W2324110651 hasConceptScore W2324110651C121608353 @default.
- W2324110651 hasConceptScore W2324110651C150194340 @default.
- W2324110651 hasConceptScore W2324110651C153911025 @default.
- W2324110651 hasConceptScore W2324110651C175211621 @default.
- W2324110651 hasConceptScore W2324110651C190727270 @default.
- W2324110651 hasConceptScore W2324110651C2779422922 @default.
- W2324110651 hasConceptScore W2324110651C2779979206 @default.
- W2324110651 hasConceptScore W2324110651C2781443798 @default.
- W2324110651 hasConceptScore W2324110651C33288867 @default.
- W2324110651 hasConceptScore W2324110651C41091548 @default.
- W2324110651 hasConceptScore W2324110651C502942594 @default.
- W2324110651 hasConceptScore W2324110651C54355233 @default.
- W2324110651 hasConceptScore W2324110651C552990157 @default.
- W2324110651 hasConceptScore W2324110651C55493867 @default.
- W2324110651 hasConceptScore W2324110651C555283112 @default.
- W2324110651 hasConceptScore W2324110651C86803240 @default.
- W2324110651 hasConceptScore W2324110651C91965660 @default.
- W2324110651 hasLocation W23241106511 @default.
- W2324110651 hasOpenAccess W2324110651 @default.
- W2324110651 hasPrimaryLocation W23241106511 @default.
- W2324110651 hasRelatedWork W1994567940 @default.
- W2324110651 hasRelatedWork W1996572424 @default.
- W2324110651 hasRelatedWork W2030085746 @default.
- W2324110651 hasRelatedWork W2049655062 @default.
- W2324110651 hasRelatedWork W2052230594 @default.
- W2324110651 hasRelatedWork W2067003561 @default.
- W2324110651 hasRelatedWork W2077632975 @default.
- W2324110651 hasRelatedWork W2082170527 @default.
- W2324110651 hasRelatedWork W2097245471 @default.
- W2324110651 hasRelatedWork W2100579175 @default.
- W2324110651 hasRelatedWork W2123992220 @default.
- W2324110651 hasRelatedWork W2141835013 @default.
- W2324110651 hasRelatedWork W2151146495 @default.
- W2324110651 hasRelatedWork W2158630016 @default.
- W2324110651 hasRelatedWork W2277801602 @default.
- W2324110651 hasRelatedWork W2336800892 @default.
- W2324110651 hasRelatedWork W2914196694 @default.
- W2324110651 hasRelatedWork W3028256588 @default.
- W2324110651 hasRelatedWork W3083466048 @default.
- W2324110651 hasRelatedWork W3153525004 @default.
- W2324110651 isParatext "false" @default.
- W2324110651 isRetracted "false" @default.
- W2324110651 magId "2324110651" @default.
- W2324110651 workType "article" @default.