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- W2324155856 abstract "Chronic HIV infection is associated with persistent immune activation and inflammation even among patients virologically suppressed on antiretroviral therapy for years. Chronic immune activation has been associated with poor outcomes--both AIDS-defining and non-AIDS-defining clinical events--and persistent CD4 T-cell depletion. The cause of chronic immune activation in well-controlled HIV infection is unknown. Proposed drivers include residual viral replication, microbial translocation, and coinfecting pathogens. Therapeutic interventions targeting immune activation are emerging, from approaches that interfere directly with activation and inflammatory pathways to those that prevent microbial translocation or decrease the availability of host target cells for the virus. In the context of the disappointing results of the interleukin-2 trials, the main challenges to developing these disease-modifying therapies include identifying an adequate target population and choosing surrogate endpoints that will provide positive proof-of-concept that the interventions will translate into long-term clinical benefit before embarking on large clinical endpoint trials." @default.
- W2324155856 created "2016-06-24" @default.
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- W2324155856 date "2011-11-01" @default.
- W2324155856 modified "2023-09-27" @default.
- W2324155856 title "Disease-Modifying Therapeutic Concepts for HIV in the Era of Highly Active Antiretroviral Therapy" @default.
- W2324155856 cites W1509269909 @default.
- W2324155856 cites W1574092316 @default.
- W2324155856 cites W1608236599 @default.
- W2324155856 cites W1767940945 @default.
- W2324155856 cites W1963759891 @default.
- W2324155856 cites W1967548282 @default.
- W2324155856 cites W1974293345 @default.
- W2324155856 cites W1975699571 @default.
- W2324155856 cites W1977485148 @default.
- W2324155856 cites W1980690767 @default.
- W2324155856 cites W1981259148 @default.
- W2324155856 cites W1981753795 @default.
- W2324155856 cites W1982879357 @default.
- W2324155856 cites W1987387726 @default.
- W2324155856 cites W2002051431 @default.
- W2324155856 cites W2004262263 @default.
- W2324155856 cites W2005141763 @default.
- W2324155856 cites W2005218441 @default.
- W2324155856 cites W2006688902 @default.
- W2324155856 cites W2008382587 @default.
- W2324155856 cites W2013561307 @default.
- W2324155856 cites W2019323140 @default.
- W2324155856 cites W2021227042 @default.
- W2324155856 cites W2026444780 @default.
- W2324155856 cites W2035634351 @default.
- W2324155856 cites W2035813371 @default.
- W2324155856 cites W2039222095 @default.
- W2324155856 cites W2040513966 @default.
- W2324155856 cites W2047385553 @default.
- W2324155856 cites W2057292199 @default.
- W2324155856 cites W2061202914 @default.
- W2324155856 cites W2063028752 @default.
- W2324155856 cites W2070542788 @default.
- W2324155856 cites W2076579763 @default.
- W2324155856 cites W2078013859 @default.
- W2324155856 cites W2082331075 @default.
- W2324155856 cites W2082371015 @default.
- W2324155856 cites W2083751424 @default.
- W2324155856 cites W2088037915 @default.
- W2324155856 cites W2089568674 @default.
- W2324155856 cites W2099106733 @default.
- W2324155856 cites W2099270831 @default.
- W2324155856 cites W2104089351 @default.
- W2324155856 cites W2104838062 @default.
- W2324155856 cites W2105213363 @default.
- W2324155856 cites W2105532585 @default.
- W2324155856 cites W2105722575 @default.
- W2324155856 cites W2105804574 @default.
- W2324155856 cites W2106164053 @default.
- W2324155856 cites W2110260408 @default.
- W2324155856 cites W2112858422 @default.
- W2324155856 cites W2113669930 @default.
- W2324155856 cites W2114497207 @default.
- W2324155856 cites W2117553644 @default.
- W2324155856 cites W2117775197 @default.
- W2324155856 cites W2122483069 @default.
- W2324155856 cites W2124058652 @default.
- W2324155856 cites W2127031590 @default.
- W2324155856 cites W2127517680 @default.
- W2324155856 cites W2130603879 @default.
- W2324155856 cites W2132122777 @default.
- W2324155856 cites W2132826589 @default.
- W2324155856 cites W2135994316 @default.
- W2324155856 cites W2138165790 @default.
- W2324155856 cites W2140573695 @default.
- W2324155856 cites W2148835789 @default.
- W2324155856 cites W2150484278 @default.
- W2324155856 cites W2150645158 @default.
- W2324155856 cites W2153136696 @default.
- W2324155856 cites W2153650518 @default.
- W2324155856 cites W2153741943 @default.
- W2324155856 cites W2157040546 @default.
- W2324155856 cites W2159360702 @default.
- W2324155856 cites W2160230582 @default.
- W2324155856 cites W2162694378 @default.
- W2324155856 cites W2166861522 @default.
- W2324155856 cites W2167148984 @default.
- W2324155856 cites W2169085525 @default.
- W2324155856 cites W2313516424 @default.
- W2324155856 cites W2319153630 @default.
- W2324155856 cites W2324402215 @default.
- W2324155856 cites W83931366 @default.