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- W2324157304 abstract "Kronik yaygin (dissemine) kandidiyazis olarak da bilinen hepatosplenik kandidiyazis (HSC) karaciger, dalak ve bobregi tutan invazif mantar enfeksiyonudur. Cocukluk cagi kanserlerinde uygulanan kemoterapi sonrasi notropeni gelisen hastalarda, giderek artan siklikta tespit edilmektedir. Kesin tani kan ve doku kulturlerinde patojenin uretilmesi veya biyopsi orneklerinde etkenin gosterilmesi ile konur. Temel tedavi yaklasimi parenteral amfoterisin B uygulamasidir. Bu yazida; evre 4 noroblastom tanisi ile kemoterapi almakta iken, febril notropeni atagi esnasinda gelisen hepatosplenik kandidiyazis nedeniyle sirtinda ve kollarinda cok sayida noduler lezyonlar gozlenen 7 yasinda bir olgu sunulmustur. Radyolojik tetkikler ve kan kulturu ile HSC tanisi alan ancak amfoterisin B tedavisine yanit vermeyen hasta, uzun sure uygulanan kaspofungin ile tedavi edilebilmistir. (J Pediatr Inf 2013; 7: 39-42) Anahtar kelimeler: Cocuk, hepatosplenik kandidiyazis, noroblastom Abstract Hepatosplenic candidiasis (HSC), also commonly known as chronic disseminated candidiasis, is a distinct form of disseminated Candida supp. infection, with predominant involvement of the liver, spleen and occasionally the kidneys. It is detected with increasing frequency in patients who developed neutropenia after chemotherapy in childhood cancers. A definitive diagnosis is made by producing the pathogen in culture or showing the pathogen in biopsy specimens. The basic approach in treatment is the use of parenteral amphothericine B. In this paper, a case of a 7 year old patient who developed a large number of nodular lesions on his back and arms in febrile neutropenic episodes while receiving chemotherapy with a diagnosis of stage 4 neuroblastoma is presented. The patient, who was diagnosed with the HSC after radiological tests and blood cultures but did not respond to treatment with amphotericin B, was only treated with caspofungin for a long time. (J Pediatr Inf 2013; 7: 39-42)" @default.
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- W2324157304 date "2013-03-14" @default.
- W2324157304 modified "2023-10-16" @default.
- W2324157304 title "Hepatosplenic Candidiasis with Generalized Cutaneous Nodular Lesions: A Case Report" @default.
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- W2324157304 doi "https://doi.org/10.5152/ced.2013.09" @default.
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