FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324217022> ?p ?o ?g. }

• W2324217022 endingPage "19308" @default.
• W2324217022 startingPage "19297" @default.
• W2324217022 abstract "The folding kinetics of G-quadruplex forming sequences is critical to their capacity to influence biological function. While G-quadruplex structure and stability have been relatively well studied, little is known about the kinetics of their folding. We employed a stopped-flow mixing technique to systematically investigate the potassium-dependent folding kinetics of telomeric RNA and DNA G-quadruplexes and RNA G-quadruplexes containing only two G-quartets formed from sequences r[(GGA)(3)GG] and r[(GGUUA)(3)GG]. Our findings suggest a folding mechanism that involves two kinetic steps with initial binding of a single K(+), irrespective of the number of G-quartets involved or whether the G-quadruplex is formed from RNA or DNA. The folding rates for telomeric RNA and DNA G-quadruplexes are comparable at near physiological [K(+)] (90 mM) (τ = ~60 ms). The folding of a 2-quartet RNA G-quadruplex with single nucleotide A loops is considerably slower (τ = ~700 ms), and we found that the time required to fold a UUA looped variant (τ > 100 s, 500 mM K(+)) exceeds the lifetimes of some regulatory RNAs. We discuss the implications of these findings with respect to the fundamental properties of G-quadruplexes and their potential functions in biology." @default.
• W2324217022 created "2016-06-24" @default.
• W2324217022 creator A5040551102 @default.
• W2324217022 creator A5059801445 @default.
• W2324217022 date "2012-11-12" @default.
• W2324217022 modified "2023-10-04" @default.
• W2324217022 title "The Kinetics and Folding Pathways of Intramolecular G-Quadruplex Nucleic Acids" @default.
• W2324217022 cites W1523125680 @default.
• W2324217022 cites W1528250934 @default.
• W2324217022 cites W1658649599 @default.
• W2324217022 cites W1964413781 @default.
• W2324217022 cites W1969089197 @default.
• W2324217022 cites W1974618862 @default.
• W2324217022 cites W1977413761 @default.
• W2324217022 cites W1981888951 @default.
• W2324217022 cites W1984375872 @default.
• W2324217022 cites W1990447102 @default.
• W2324217022 cites W1993726540 @default.
• W2324217022 cites W1993864575 @default.
• W2324217022 cites W1994809040 @default.
• W2324217022 cites W2006397579 @default.
• W2324217022 cites W2009581739 @default.
• W2324217022 cites W2012768611 @default.
• W2324217022 cites W2019190761 @default.
• W2324217022 cites W2020693276 @default.
• W2324217022 cites W2023356131 @default.
• W2324217022 cites W2025336895 @default.
• W2324217022 cites W2025374847 @default.
• W2324217022 cites W2029987509 @default.
• W2324217022 cites W2033286169 @default.
• W2324217022 cites W2036547750 @default.
• W2324217022 cites W2036707808 @default.
• W2324217022 cites W2038304204 @default.
• W2324217022 cites W2039035269 @default.
• W2324217022 cites W2039241171 @default.
• W2324217022 cites W2040858214 @default.
• W2324217022 cites W2042377388 @default.
• W2324217022 cites W2044483297 @default.
• W2324217022 cites W2045868610 @default.
• W2324217022 cites W2047210598 @default.
• W2324217022 cites W2048748100 @default.
• W2324217022 cites W2052460325 @default.
• W2324217022 cites W2055556773 @default.
• W2324217022 cites W2055892534 @default.
• W2324217022 cites W2062724831 @default.
• W2324217022 cites W2062779626 @default.
• W2324217022 cites W2073204556 @default.
• W2324217022 cites W2075747958 @default.
• W2324217022 cites W2076843089 @default.
• W2324217022 cites W2079768304 @default.
• W2324217022 cites W2081781483 @default.
• W2324217022 cites W2083602966 @default.
• W2324217022 cites W2084937218 @default.
• W2324217022 cites W2087011288 @default.
• W2324217022 cites W2088635998 @default.
• W2324217022 cites W2093713534 @default.
• W2324217022 cites W2107208446 @default.
• W2324217022 cites W2107744687 @default.
• W2324217022 cites W2109887615 @default.
• W2324217022 cites W2111271543 @default.
• W2324217022 cites W2129013431 @default.
• W2324217022 cites W2130652515 @default.
• W2324217022 cites W2137986693 @default.
• W2324217022 cites W2142852652 @default.
• W2324217022 cites W2147643191 @default.
• W2324217022 cites W2150490516 @default.
• W2324217022 cites W2153207180 @default.
• W2324217022 cites W2163533539 @default.
• W2324217022 cites W2165072963 @default.
• W2324217022 cites W2167586689 @default.
• W2324217022 cites W2169230340 @default.
• W2324217022 cites W2169745877 @default.
• W2324217022 cites W2315475605 @default.
• W2324217022 cites W2315967566 @default.
• W2324217022 cites W2322733915 @default.
• W2324217022 cites W4253789658 @default.
• W2324217022 doi "https://doi.org/10.1021/ja309851t" @default.
• W2324217022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23113843" @default.
• W2324217022 hasPublicationYear "2012" @default.
• W2324217022 type Work @default.
• W2324217022 sameAs 2324217022 @default.
• W2324217022 citedByCount "130" @default.
• W2324217022 countsByYear W23242170222012 @default.
• W2324217022 countsByYear W23242170222013 @default.
• W2324217022 countsByYear W23242170222014 @default.
• W2324217022 countsByYear W23242170222015 @default.
• W2324217022 countsByYear W23242170222016 @default.
• W2324217022 countsByYear W23242170222017 @default.
• W2324217022 countsByYear W23242170222018 @default.
• W2324217022 countsByYear W23242170222019 @default.
• W2324217022 countsByYear W23242170222020 @default.
• W2324217022 countsByYear W23242170222021 @default.
• W2324217022 countsByYear W23242170222022 @default.
• W2324217022 countsByYear W23242170222023 @default.
• W2324217022 crossrefType "journal-article" @default.
• W2324217022 hasAuthorship W2324217022A5040551102 @default.
• W2324217022 hasAuthorship W2324217022A5059801445 @default.
• W2324217022 hasConcept C104317684 @default.

• next