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- W2324251341 abstract "Oral Itraconazole has proven to be a superior drug for antifungal prophylaxis in OLTx, however very little data are available in the literature on its impact of the immunosuppressant trough levels. we aimed to: a) evaluate the incidence of fungal infection during oral Itraconazole prophylaxis b) evaluate effect of Itraconazole on immunosuppressant levels. Methods: we enrolled 98 patients that underwent OLTx at our centre between January 2007 to July 2009. All had received oral Itraconazole (100mg/day for 3 months) as antifungal prophylaxis. 1,3-b,D-glucan or galactomannan assays and culture test were performed as well as immunosuppressant trough levels. Results: 97 out of 98 patients followed were negative for Aspergillus and Candida antigens in serum at each time point of the study. Itraconazole induced an immediate and average increase of about 30% in the immunosuppressant trough levels as soon as the drug was started, though this effect disappeared immediately after the oral prophylaxis was suspended. In conclusion, oral Itraconazole is a safe and effective drug when used as antifungal prophylaxis and it induces a constant and significant increase of the immunosuppressant trough level most likely acting as booster, that may lead to the end result of a reduction in anti-rejection drugs." @default.
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- W2324251341 date "2012-11-01" @default.
- W2324251341 modified "2023-10-17" @default.
- W2324251341 title "Universal Oral Itraconazole Prophylaxis in Liver Transplantation: Boostering Immunosuppressive Drugs While Protecting from Fungal Infection" @default.
- W2324251341 doi "https://doi.org/10.1097/00007890-201211271-00730" @default.
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