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• W2324252587 abstract "Event Abstract Back to Event Immobilization of quorum sensing inhibitors to develop antibacterial biomaterials Aditi Taunk1, George Iskander1, Kitty Ka Kit Ho1, Mark D. Willcox2 and Naresh Kumar1 1 University of New South Wales, School of Chemistry, Australia 2 University of New South Wales, School of Optometry and Vision Science, Australia Introduction: The use of life-saving biomaterial implants and medical devices has increased tremendously over the past few years. One major complication with the long term use of biomaterials is bacterial biofilm formation. About 60-70% of hospital-acquired infections are due to implanted medical devices[1]. Treatment or removal of these infected devices is often troublesome for the patient resulting in high rates of morbidity and mortality as well as high medical cost[2],[3]. Also, rapid development of antibacterial resistance and lack of efficient strategies that can reduce the incidence of bacterial infections have made this a challenging problem to overcome. Therefore, in order to prevent infections associated with medical devices, coatings that interfere with the bacterial communication pathways known as quorum sensing (QS) instead of killing the bacteria have been developed. Materials and Methods: In this study, potent quorum sensing inhibitors (QSI) including halogenated furanones (FUs) and dihydropyrrolones (DHPs) were immobilized on surfaces. The FUs were attached via a non-specific nitrene insertion method [Fig 1], and DHPs with free carboxylic acid group were synthesized and attached covalently on amine functionalized surface via EDC/NHS coupling reaction [Fig 2]. The covalent attachment of DHPs was characterized by X-ray photoelectron spectroscopy (XPS) and contact angle measurement. Antibacterial activity of the DHP surfaces was assessed against two common pathogens, Staphylococcus aureus and Pseudomonas aeruginosa, using confocal laser scanning microscopy (CLSM). Results and Discussion: The XPS and contact angle measurements confirmed the successful attachment of brominated FUs via the nitrene insertion reaction and DHPs via EDC/NHS reaction. XPS detection of 0.17-0.74% Br from FUs and 0.17% F and 0.3% Br from 4-fluorophenyl and 4-bromophenyl DHP confirmed the efficacy of the coating strategy. All FU and DHP coated surfaces were able to significantly reduce the formation of biofilm against both S. aureus and P. aeruginosa. The activity of the coating was dependent upon the type of substituent present on the phenyl group of the DHP compound. For example, the ortho-fluorophenyl DHP (DHP-2) exhibited 79% reduction in bacterial adhesion against S. aureus and para-fluorophenyl DHP (DHP-3) exhibited 70% reduction against P. aeruginosa. The results were found to be comparable to other DHP coatings developed in previous studies. Conclusion: The furanone and DHP immobilised surfaces show high levels of inhibition of bacterial biofilm formation and may represent an effective strategy to develop new antibacterial coatings. UNSW Analytical Center for XPS, NMR data; UNSW Biomedical Imaging Facility for confocal microscopy; Australian government for the Australian Postgraduate Award (APA) scholarshipReferences:[1] Bryers, J. D. Medical biofilms. Biotechnol. Bioeng.100, 1–18 (2008).[2] Cruickshank, M. & Ferguson, J. Reducing harm to patients from health care associated infection : the role of surveillance. (2008)[3] Australian Guidlines for the prevention and control of infection in healthcare-executive summary. Aust. Goverment - Natl. Heal. Med. Res. Counc. (2010). Keywords: Bacteria, Infection, biomaterial, Surface modification Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Anti-infective biomaterials Citation: Taunk A, Iskander G, Ho K, Willcox MD and Kumar N (2016). Immobilization of quorum sensing inhibitors to develop antibacterial biomaterials. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.02320 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Aditi Taunk George Iskander Kitty Ka Kit Ho Mark D Willcox Naresh Kumar Google Aditi Taunk George Iskander Kitty Ka Kit Ho Mark D Willcox Naresh Kumar Google Scholar Aditi Taunk George Iskander Kitty Ka Kit Ho Mark D Willcox Naresh Kumar PubMed Aditi Taunk George Iskander Kitty Ka Kit Ho Mark D Willcox Naresh Kumar Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2324252587 title "Immobilization of quorum sensing inhibitors to develop antibacterial biomaterials" @default.
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