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- W2324257036 abstract "癌抑制遺伝子のひとつであるp53遺伝子の変異が,種々のヒト癌で報告されている.今回我々は,肝細胞癌におけるp53蛋白の発現異常を,凍結切片を用いて免疫組織化学的に検索し,同時に増殖関連マーカーであるKi-67についても免疫染色を行い,p53遺伝子の変異と腫瘍の分化,増殖との関連を検討した.その結果,手術で得られた肝細胞癌組織30例中7例(23.3%)でp53蛋白の発現を認めた.高分化型肝癌4例は全てp53蛋白陰性,中分化型では16例中2例(12.5%),低分化型では10例中5例(50.0%)が陽性であった.また,Ki-67標識率にもとづく腫瘍の増殖活性を比較すると,p53陽性群は陰性群に比し有意に増殖活性が高かった.以上より,肝細胞癌におけるp53遺伝子の変異は,より分化度が低く,増殖活性の高い腫瘍で生じていることが示唆された." @default.
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- W2324257036 date "1993-01-01" @default.
- W2324257036 modified "2023-09-26" @default.
- W2324257036 title "Immunohistochemical study on p53 expression in hepatocellular carcinomas." @default.
- W2324257036 doi "https://doi.org/10.2957/kanzo.34.606" @default.
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