Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324257772> ?p ?o ?g. }
- W2324257772 endingPage "1407" @default.
- W2324257772 startingPage "1392" @default.
- W2324257772 abstract "The success rate to achieve clinical approval of drugs developed to treat diseases of the central nervous system (CNS) is the lowest of all disease indications. A large contributor to this poor success rate is failure of small molecules to pass through the blood-brain barrier (BBB), a barrier composed of capillary endothelial cells connected by tight junctions that functions to extrude xenobiotics from the brain. Designing small molecules to be BBB penetrant has been the subject of intensive research and has resulted in a series of guidelines to attain the best possible chances of BBB penetration. This review will analyze the current state of thinking in ranking the importance of various physicochemical properties required to select BBB penetrant molecules, describe model systems to determine BBB penetration, summarize data analysis methods and provide an outlook on further developments in the field. Keywords: Blood-brain barrier, Drug-likeness, Central Nervous System, Neuropharmacology, Physicochemical Properties, Drug Design." @default.
- W2324257772 created "2016-06-24" @default.
- W2324257772 creator A5065214170 @default.
- W2324257772 date "2016-05-13" @default.
- W2324257772 modified "2023-09-30" @default.
- W2324257772 title "Selecting Good ‘Drug-Like’ Properties to Optimize Small Molecule Blood-Brain Barrier Penetration" @default.
- W2324257772 cites W128151115 @default.
- W2324257772 cites W1422457926 @default.
- W2324257772 cites W1549213315 @default.
- W2324257772 cites W1568560565 @default.
- W2324257772 cites W1581321319 @default.
- W2324257772 cites W1783939843 @default.
- W2324257772 cites W183066433 @default.
- W2324257772 cites W1837885345 @default.
- W2324257772 cites W1895506743 @default.
- W2324257772 cites W1895993106 @default.
- W2324257772 cites W1965522214 @default.
- W2324257772 cites W1971513938 @default.
- W2324257772 cites W1972766890 @default.
- W2324257772 cites W1973091091 @default.
- W2324257772 cites W1974129665 @default.
- W2324257772 cites W1974290383 @default.
- W2324257772 cites W1981625417 @default.
- W2324257772 cites W1981851444 @default.
- W2324257772 cites W1982261968 @default.
- W2324257772 cites W1987825764 @default.
- W2324257772 cites W1988137843 @default.
- W2324257772 cites W1990250882 @default.
- W2324257772 cites W1991064261 @default.
- W2324257772 cites W1991443437 @default.
- W2324257772 cites W1992459928 @default.
- W2324257772 cites W1992601093 @default.
- W2324257772 cites W1995603244 @default.
- W2324257772 cites W1996719014 @default.
- W2324257772 cites W2000208781 @default.
- W2324257772 cites W2000617311 @default.
- W2324257772 cites W2001726213 @default.
- W2324257772 cites W2002352450 @default.
- W2324257772 cites W2002741001 @default.
- W2324257772 cites W2003641863 @default.
- W2324257772 cites W2004030603 @default.
- W2324257772 cites W2005447377 @default.
- W2324257772 cites W2006840751 @default.
- W2324257772 cites W2006846454 @default.
- W2324257772 cites W2007859813 @default.
- W2324257772 cites W2011578064 @default.
- W2324257772 cites W2012628424 @default.
- W2324257772 cites W2013280216 @default.
- W2324257772 cites W2014693252 @default.
- W2324257772 cites W2016575780 @default.
- W2324257772 cites W2018700017 @default.
- W2324257772 cites W2018872680 @default.
- W2324257772 cites W2022113679 @default.
- W2324257772 cites W2024533743 @default.
- W2324257772 cites W2026976753 @default.
- W2324257772 cites W2030028063 @default.
- W2324257772 cites W2030215451 @default.
- W2324257772 cites W2033756424 @default.
- W2324257772 cites W2035128513 @default.
- W2324257772 cites W2036298287 @default.
- W2324257772 cites W2037006599 @default.
- W2324257772 cites W2040972896 @default.
- W2324257772 cites W2045312970 @default.
- W2324257772 cites W2045529054 @default.
- W2324257772 cites W2046826638 @default.
- W2324257772 cites W2046827775 @default.
- W2324257772 cites W2054406104 @default.
- W2324257772 cites W2056449991 @default.
- W2324257772 cites W2056475298 @default.
- W2324257772 cites W2057928306 @default.
- W2324257772 cites W2058780134 @default.
- W2324257772 cites W2062271440 @default.
- W2324257772 cites W2065457701 @default.
- W2324257772 cites W2067223842 @default.
- W2324257772 cites W2067733328 @default.
- W2324257772 cites W2068337543 @default.
- W2324257772 cites W2072063239 @default.
- W2324257772 cites W2074176940 @default.
- W2324257772 cites W2078877172 @default.
- W2324257772 cites W2081293777 @default.
- W2324257772 cites W2083025840 @default.
- W2324257772 cites W2085638132 @default.
- W2324257772 cites W2087020733 @default.
- W2324257772 cites W2088936498 @default.
- W2324257772 cites W2090945850 @default.
- W2324257772 cites W2091758060 @default.
- W2324257772 cites W2093283758 @default.
- W2324257772 cites W2093883044 @default.
- W2324257772 cites W2098472712 @default.
- W2324257772 cites W2099718046 @default.
- W2324257772 cites W2103312948 @default.
- W2324257772 cites W2104290477 @default.
- W2324257772 cites W2105649494 @default.
- W2324257772 cites W2108141803 @default.
- W2324257772 cites W2110869886 @default.
- W2324257772 cites W2112260434 @default.
- W2324257772 cites W2112893277 @default.
- W2324257772 cites W2116353632 @default.