Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324259310> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W2324259310 endingPage "843" @default.
- W2324259310 startingPage "839" @default.
- W2324259310 abstract "The development of sensitive immunofluorescent technics for the detection of platelet antibodies has stimulated renewed interest in the field of platelet immunology. However, the analysis of multispecific sera containing both HLA and platelet-specific antibodies requires cumbersome absorption technics and relatively large quantities of serum. In this report we describe the feasibility of screening sera from multiparous women and multitransfused patients for platelet-specific antibodies using blocking inhibition with a murine monoclonal antibody against HLA A, B, and C antigens followed by platelet immunofluorescence. Platelet immunofluorescence detected anti-A antibodies in sera from some blood group O donors. Known HLA antibodies usually were detectable by platelet immunofluorescence, but false-positive reactions occurred frequently. Analysis of sera from recipients of multiple platelet transfusions revealed that 47/78 (60.2%) were positive by platelet immunofluorescence. After blocking inhibition-persistent fluorescence was observed with 11/29 sera (37.9%), suggesting the presence of platelet-specific antibodies. Absorption studies performed on two of these sera revealed that antibody activity was removed by absorption with platelets but not lymphocytes. Platelet immunofluorescence combined with monoclonal antibody blocking inhibition proved to be a valuable tool to distinguish between HLA and platelet-specific antibodies." @default.
- W2324259310 created "2016-06-24" @default.
- W2324259310 creator A5010954538 @default.
- W2324259310 creator A5047931752 @default.
- W2324259310 date "1983-12-01" @default.
- W2324259310 modified "2023-10-05" @default.
- W2324259310 title "The Detection of Platelet Antibodies Using a Modified Platelet Immunofluorescence Test" @default.
- W2324259310 doi "https://doi.org/10.1093/ajcp/80.6.839" @default.
- W2324259310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6356880" @default.
- W2324259310 hasPublicationYear "1983" @default.
- W2324259310 type Work @default.
- W2324259310 sameAs 2324259310 @default.
- W2324259310 citedByCount "3" @default.
- W2324259310 crossrefType "journal-article" @default.
- W2324259310 hasAuthorship W2324259310A5010954538 @default.
- W2324259310 hasAuthorship W2324259310A5047931752 @default.
- W2324259310 hasConcept C147483822 @default.
- W2324259310 hasConcept C153911025 @default.
- W2324259310 hasConcept C159654299 @default.
- W2324259310 hasConcept C185592680 @default.
- W2324259310 hasConcept C203014093 @default.
- W2324259310 hasConcept C2778236600 @default.
- W2324259310 hasConcept C45121317 @default.
- W2324259310 hasConcept C542903549 @default.
- W2324259310 hasConcept C71924100 @default.
- W2324259310 hasConcept C86803240 @default.
- W2324259310 hasConcept C89560881 @default.
- W2324259310 hasConceptScore W2324259310C147483822 @default.
- W2324259310 hasConceptScore W2324259310C153911025 @default.
- W2324259310 hasConceptScore W2324259310C159654299 @default.
- W2324259310 hasConceptScore W2324259310C185592680 @default.
- W2324259310 hasConceptScore W2324259310C203014093 @default.
- W2324259310 hasConceptScore W2324259310C2778236600 @default.
- W2324259310 hasConceptScore W2324259310C45121317 @default.
- W2324259310 hasConceptScore W2324259310C542903549 @default.
- W2324259310 hasConceptScore W2324259310C71924100 @default.
- W2324259310 hasConceptScore W2324259310C86803240 @default.
- W2324259310 hasConceptScore W2324259310C89560881 @default.
- W2324259310 hasIssue "6" @default.
- W2324259310 hasLocation W23242593101 @default.
- W2324259310 hasLocation W23242593102 @default.
- W2324259310 hasOpenAccess W2324259310 @default.
- W2324259310 hasPrimaryLocation W23242593101 @default.
- W2324259310 hasRelatedWork W1973692620 @default.
- W2324259310 hasRelatedWork W1989289676 @default.
- W2324259310 hasRelatedWork W1997063113 @default.
- W2324259310 hasRelatedWork W2003870817 @default.
- W2324259310 hasRelatedWork W2009889818 @default.
- W2324259310 hasRelatedWork W2037509311 @default.
- W2324259310 hasRelatedWork W2073262237 @default.
- W2324259310 hasRelatedWork W2162389703 @default.
- W2324259310 hasRelatedWork W2317962315 @default.
- W2324259310 hasRelatedWork W2324259310 @default.
- W2324259310 hasVolume "80" @default.
- W2324259310 isParatext "false" @default.
- W2324259310 isRetracted "false" @default.
- W2324259310 magId "2324259310" @default.
- W2324259310 workType "article" @default.