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- W2324279107 abstract "The novel iridium(III) complex 1 was verified as a potent inhibitor of the TNF-α–TNFR protein–protein interaction in vitro and in cellulo. The iridium(III) center plays a critical role in organizing the structure of the bioactive metal complex, as the isolated ligands were found to be completely inactive. Both iridium enantiomers inhibited TNF-α-induced NF-κB activity and TNF-α–TNFR binding. 1 represents a promising scaffold for the further development of more potent organometallic TNF-α inhibitors." @default.
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- W2324279107 date "2016-04-14" @default.
- W2324279107 modified "2023-10-17" @default.
- W2324279107 title "Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor-α" @default.
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- W2324279107 doi "https://doi.org/10.1021/acs.jmedchem.6b00112" @default.
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