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- W2324291303 abstract "The application of high-volume hemofiltration (HV-HF) as adjunctive therapy in severe sepsis or systemic inflammatory response syndrome (SIRS) may improve outcome in critically ill patients, although this hypothesis remains a subject of significant debate. The original theory suggested beneficial effects of HV-HF through the removal of pro-inflammatory mediators. More recently, this theory was thought to be insufficient and novel hypotheses were proposed. Unfortunately, large, randomized controlled trials (RCTs) that are sufficiently powered for clinically meaningful outcomes are lacking. However, the effects of HV-HF in sepsis or SIRS have been studied in humans in small RCTs and observational studies, as well as in animal models. In humans, comparison among studies is hampered by the heterogeneity of both the study populations and hemofiltration strategies. Animal models overcome the problem of heterogeneity; however, they poorly mimic clinical practice. Of note, no two studies have applied the same definition for HV-HF. The present review discusses the new theories on HV-HF and its role as an adjunctive therapy in severe sepsis or SIRS, considering the literature over the last 15 years. In addition, the urge for a consensus definition for HV-HF is discussed, as well as the utility for future studies. Adv Sepsis 2007;6(2):47‐57." @default.
- W2324291303 created "2016-06-24" @default.
- W2324291303 creator A5024748941 @default.
- W2324291303 date "2007-01-01" @default.
- W2324291303 modified "2023-09-27" @default.
- W2324291303 title "High-Volume Hemofiltration as Adjunctive Therapy for Sepsis and Systemic Inflammatory Response Syndrome: Background, Definition and a Descriptive Analysis of Animal and Human Studies" @default.
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