Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324307206> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2324307206 endingPage "70" @default.
- W2324307206 startingPage "765" @default.
- W2324307206 abstract "The metabolism and disposition of acetaminophen (APAP) and a non-hepatotoxic regioisomer, 3'-hydroxyacetanilide (AMAP), were investigated in the mouse using 14C-labeled analogues. Covalent binding of metabolites of both compounds was observed on the order of 1 nmol/mg tissue protein. AMAP binding was much higher than that of APAP at 1 hr, but by 24 hr, AMAP binding was significantly lower than that of APAP. APAP binding peaked at 3 hr and did not decrease significantly thereafter. Despite the high early levels of covalent binding, AMAP was not as effective in causing glutathione depletion as was APAP. This was reflected in the urinary metabolite profiles of the two compounds. Approximately twice as much APAP was cleared through thioether conjugation compared to AMAP, based on an analysis of urinary metabolites. These results and results of other studies suggest that electrophilic metabolites of AMAP are more reactive than those of APAP, and do not diffuse as far from their site of formation, which may spare some critical target proteins from damage." @default.
- W2324307206 created "2016-06-24" @default.
- W2324307206 creator A5068508773 @default.
- W2324307206 creator A5075413549 @default.
- W2324307206 creator A5087288886 @default.
- W2324307206 date "1990-09-01" @default.
- W2324307206 modified "2023-09-23" @default.
- W2324307206 title "Hepatic protein arylation, glutathione depletion, and metabolite profiles of acetaminophen and a non-hepatotoxic regioisomer, 3'-hydroxyacetanilide, in the mouse." @default.
- W2324307206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1981734" @default.
- W2324307206 hasPublicationYear "1990" @default.
- W2324307206 type Work @default.
- W2324307206 sameAs 2324307206 @default.
- W2324307206 citedByCount "21" @default.
- W2324307206 countsByYear W23243072062012 @default.
- W2324307206 countsByYear W23243072062013 @default.
- W2324307206 countsByYear W23243072062015 @default.
- W2324307206 countsByYear W23243072062016 @default.
- W2324307206 countsByYear W23243072062018 @default.
- W2324307206 countsByYear W23243072062019 @default.
- W2324307206 countsByYear W23243072062021 @default.
- W2324307206 countsByYear W23243072062022 @default.
- W2324307206 crossrefType "journal-article" @default.
- W2324307206 hasAuthorship W2324307206A5068508773 @default.
- W2324307206 hasAuthorship W2324307206A5075413549 @default.
- W2324307206 hasAuthorship W2324307206A5087288886 @default.
- W2324307206 hasConcept C181199279 @default.
- W2324307206 hasConcept C185592680 @default.
- W2324307206 hasConcept C195289149 @default.
- W2324307206 hasConcept C2777477808 @default.
- W2324307206 hasConcept C2778722691 @default.
- W2324307206 hasConcept C2779444094 @default.
- W2324307206 hasConcept C538909803 @default.
- W2324307206 hasConcept C55493867 @default.
- W2324307206 hasConcept C62231903 @default.
- W2324307206 hasConcept C71240020 @default.
- W2324307206 hasConceptScore W2324307206C181199279 @default.
- W2324307206 hasConceptScore W2324307206C185592680 @default.
- W2324307206 hasConceptScore W2324307206C195289149 @default.
- W2324307206 hasConceptScore W2324307206C2777477808 @default.
- W2324307206 hasConceptScore W2324307206C2778722691 @default.
- W2324307206 hasConceptScore W2324307206C2779444094 @default.
- W2324307206 hasConceptScore W2324307206C538909803 @default.
- W2324307206 hasConceptScore W2324307206C55493867 @default.
- W2324307206 hasConceptScore W2324307206C62231903 @default.
- W2324307206 hasConceptScore W2324307206C71240020 @default.
- W2324307206 hasIssue "5" @default.
- W2324307206 hasLocation W23243072061 @default.
- W2324307206 hasOpenAccess W2324307206 @default.
- W2324307206 hasPrimaryLocation W23243072061 @default.
- W2324307206 hasRelatedWork W1752674170 @default.
- W2324307206 hasRelatedWork W187868879 @default.
- W2324307206 hasRelatedWork W2015087470 @default.
- W2324307206 hasRelatedWork W2038690071 @default.
- W2324307206 hasRelatedWork W2056763067 @default.
- W2324307206 hasRelatedWork W2074404018 @default.
- W2324307206 hasRelatedWork W2143542298 @default.
- W2324307206 hasRelatedWork W2164283682 @default.
- W2324307206 hasRelatedWork W2222772859 @default.
- W2324307206 hasRelatedWork W2324307206 @default.
- W2324307206 hasVolume "18" @default.
- W2324307206 isParatext "false" @default.
- W2324307206 isRetracted "false" @default.
- W2324307206 magId "2324307206" @default.
- W2324307206 workType "article" @default.