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• W2324335955 abstract "The human immunodeficiency virus type1 (HIV-1) promoter, the long terminal repeat (LTR), is central to regulating many aspects of viral life cycle dynamics. After viral integration into the host genome, the interactions of host and viral factors with the regulatory elements in the LTR govern viral gene expression, contributing to formation of either a productive transcriptional state or an inactive one. The molecular architecture of the LTR, especially due to the nucleosomal packaging, presents DNA binding elements to cellular transcription factors not only to sites that are upstream of the transcriptional start site but also to regions of the promoter that are downstream of the start site. The importance of the downstream sites has been appreciated specifically in imposing a fine-tuning on the tightly regulated process of gene expression under the control of HIV-1 LTR. This report provides a comprehensive review of the HIV-1 LTR interactions with the transcription factors in the downstream region and summarizes the functional impact of these events on viral gene expression." @default.
• W2324335955 created "2016-06-24" @default.
• W2324335955 creator A5034657105 @default.
• W2324335955 date "2014-06-02" @default.
• W2324335955 modified "2023-10-18" @default.
• W2324335955 title "Role of Downstream Elements in Transcriptional Regulation of the HIV-1 Promoter" @default.
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• W2324335955 doi "https://doi.org/10.15406/jhvrv.2014.01.00006" @default.
• W2324335955 hasPublicationYear "2014" @default.
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