FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324350054> ?p ?o ?g. }

• W2324350054 endingPage "483" @default.
• W2324350054 startingPage "472" @default.
• W2324350054 abstract "Protein kinase RNA activated (PKR) is a crucial mediator of anti-viral responses but is reported to be activated by multiple non-viral stimuli. However, mechanisms underlying PKR activation, particularly in response to bacterial infection, remain poorly understood. We have investigated mechanisms of PKR activation in human primary monocyte-derived dendritic cells in response to infection by Chlamydia trachomatis. Infection resulted in potent activation of PKR that was dependent on TLR4 and MyD88 signalling. NADPH oxidase was dispensable for activation of PKR as cells from chronic granulomatous disease (CGD) patients, or mice that lack NADPH oxidase activity, had equivalent or elevated PKR activation. Significantly, stimulation of cells with endoplasmic reticulum (ER) stress-inducing agents resulted in potent activation of PKR that was blocked by an inhibitor of IRE1α RNAse activity. Crucially, infection resulted in robust IRE1α RNAse activity that was dependent on TLR4 signalling and inhibition of IRE1α RNAse activity prevented PKR activation. Finally, we demonstrate that TLR4/IRE1α mediated PKR activation is required for the enhancement of interferon-β production following C. trachomatis infection. Thus, we provide evidence of a novel mechanism of PKR activation requiring ER stress signalling that occurs as a consequence of TLR4 stimulation during bacterial infection and contributes to inflammatory responses." @default.
• W2324350054 created "2016-06-24" @default.
• W2324350054 creator A5005274858 @default.
• W2324350054 creator A5041638911 @default.
• W2324350054 creator A5047404265 @default.
• W2324350054 creator A5075168290 @default.
• W2324350054 creator A5081032339 @default.
• W2324350054 creator A5081522653 @default.
• W2324350054 creator A5083380214 @default.
• W2324350054 creator A5084650430 @default.
• W2324350054 creator A5090346729 @default.
• W2324350054 creator A5090925312 @default.
• W2324350054 date "2016-07-01" @default.
• W2324350054 modified "2023-09-24" @default.
• W2324350054 title "IRE1α mediates PKR activation in response to Chlamydia trachomatis infection" @default.
• W2324350054 cites W1534378060 @default.
• W2324350054 cites W1699321428 @default.
• W2324350054 cites W1770374902 @default.
• W2324350054 cites W1892690144 @default.
• W2324350054 cites W1964906621 @default.
• W2324350054 cites W1966591175 @default.
• W2324350054 cites W1974099977 @default.
• W2324350054 cites W1985538633 @default.
• W2324350054 cites W1990122501 @default.
• W2324350054 cites W1993688639 @default.
• W2324350054 cites W1996120614 @default.
• W2324350054 cites W2003755766 @default.
• W2324350054 cites W2013996883 @default.
• W2324350054 cites W2023142724 @default.
• W2324350054 cites W2025888779 @default.
• W2324350054 cites W2027821655 @default.
• W2324350054 cites W2036505189 @default.
• W2324350054 cites W2036853011 @default.
• W2324350054 cites W2049874360 @default.
• W2324350054 cites W2057628686 @default.
• W2324350054 cites W2064138946 @default.
• W2324350054 cites W2071830962 @default.
• W2324350054 cites W2088978171 @default.
• W2324350054 cites W2089198803 @default.
• W2324350054 cites W2090923264 @default.
• W2324350054 cites W2092766784 @default.
• W2324350054 cites W2094415496 @default.
• W2324350054 cites W2100875904 @default.
• W2324350054 cites W2102087178 @default.
• W2324350054 cites W2111428445 @default.
• W2324350054 cites W2111793830 @default.
• W2324350054 cites W2119828139 @default.
• W2324350054 cites W2124334491 @default.
• W2324350054 cites W2132699693 @default.
• W2324350054 cites W2134873157 @default.
• W2324350054 cites W2143001687 @default.
• W2324350054 cites W2143668307 @default.
• W2324350054 cites W2147546596 @default.
• W2324350054 cites W2152057471 @default.
• W2324350054 cites W2153878316 @default.
• W2324350054 cites W2158837517 @default.
• W2324350054 cites W2159412259 @default.
• W2324350054 cites W2160885923 @default.
• W2324350054 cites W2164713036 @default.
• W2324350054 cites W2164868253 @default.
• W2324350054 cites W2183361684 @default.
• W2324350054 doi "https://doi.org/10.1016/j.micinf.2016.03.010" @default.
• W2324350054 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4936793" @default.
• W2324350054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27021640" @default.
• W2324350054 hasPublicationYear "2016" @default.
• W2324350054 type Work @default.
• W2324350054 sameAs 2324350054 @default.
• W2324350054 citedByCount "29" @default.
• W2324350054 countsByYear W23243500542017 @default.
• W2324350054 countsByYear W23243500542018 @default.
• W2324350054 countsByYear W23243500542019 @default.
• W2324350054 countsByYear W23243500542020 @default.
• W2324350054 countsByYear W23243500542021 @default.
• W2324350054 countsByYear W23243500542022 @default.
• W2324350054 countsByYear W23243500542023 @default.
• W2324350054 crossrefType "journal-article" @default.
• W2324350054 hasAuthorship W2324350054A5005274858 @default.
• W2324350054 hasAuthorship W2324350054A5041638911 @default.
• W2324350054 hasAuthorship W2324350054A5047404265 @default.
• W2324350054 hasAuthorship W2324350054A5075168290 @default.
• W2324350054 hasAuthorship W2324350054A5081032339 @default.
• W2324350054 hasAuthorship W2324350054A5081522653 @default.
• W2324350054 hasAuthorship W2324350054A5083380214 @default.
• W2324350054 hasAuthorship W2324350054A5084650430 @default.
• W2324350054 hasAuthorship W2324350054A5090346729 @default.
• W2324350054 hasAuthorship W2324350054A5090925312 @default.
• W2324350054 hasBestOaLocation W23243500541 @default.
• W2324350054 hasConcept C139447449 @default.
• W2324350054 hasConcept C158617107 @default.
• W2324350054 hasConcept C161238802 @default.
• W2324350054 hasConcept C184235292 @default.
• W2324350054 hasConcept C203014093 @default.
• W2324350054 hasConcept C2776070231 @default.
• W2324350054 hasConcept C2776178377 @default.
• W2324350054 hasConcept C2777391075 @default.
• W2324350054 hasConcept C2777479484 @default.
• W2324350054 hasConcept C62478195 @default.
• W2324350054 hasConcept C82495950 @default.

• next