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• W2324383231 endingPage "1531" @default.
• W2324383231 startingPage "1524" @default.
• W2324383231 abstract "Biomechanical forces are central in tumor progression and response to treatment. This becomes more important in brain cancers where tumors are surrounded by tissues with different mechanical properties. Existing mathematical models ignore direct mechanical interactions of the tumor with the normal brain. Here, we developed a clinically relevant model, which predicts tumor growth accounting directly for mechanical interactions. A three-dimensional model of the gray and white matter and the cerebrospinal fluid was constructed from magnetic resonance images of a normal brain. Subsequently, a biphasic tissue growth theory for an initial tumor seed was employed, incorporating the effects of radiotherapy. Additionally, three different sets of brain tissue properties taken from the literature were used to investigate their effect on tumor growth. Results show the evolution of solid stress and interstitial fluid pressure within the tumor and the normal brain. Heterogeneous distribution of the solid stress exerted on the tumor resulted in a 35% spatial variation in cancer cell proliferation. Interestingly, the model predicted that distant from the tumor, normal tissues still undergo significant deformations while it was found that intratumoral fluid pressure is elevated. Our predictions relate to clinical symptoms of brain cancers and present useful tools for therapy planning." @default.
• W2324383231 created "2016-06-24" @default.
• W2324383231 creator A5010480156 @default.
• W2324383231 creator A5057504407 @default.
• W2324383231 date "2016-06-01" @default.
• W2324383231 modified "2023-10-14" @default.
• W2324383231 title "Biphasic modeling of brain tumor biomechanics and response to radiation treatment" @default.
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• W2324383231 doi "https://doi.org/10.1016/j.jbiomech.2016.03.029" @default.
• W2324383231 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4921059" @default.
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• W2324383231 hasPublicationYear "2016" @default.
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