FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2324391007> ?p ?o ?g. }

• W2324391007 abstract "We demonstrate the stepwise assembly of a fully addressable polycyclic DNA hexagon nanonetwork for the preparation of a four-ring system, one of the biggest networks yet constructed from tripodal building blocks. We find that the yield exhibits a distinct upper level <100%, a fundamental problem of thermodynamic DNA assembly that appears to have been overlooked in the DNA nanotechnology literature. A simplistic model based on a single step-yield parameterycanquantitativelydescribethetotalyieldofDNAassembliesinone-potreactionsasY= yduplex n , with n the number of hybridization steps. Experimental errors introducing deviations from perfect stoichiometry and the thermodynamics of hybridization equilibria contribute to decreasing thevalueofyduplex(onaveragey= 0.96forour10base pairhybridization). Forthefour-ring system (n=31),thetotalyieldisthuslessthan30%,whichisclearlyunsatisfactoryifbiggernanoconstructs ofthisclassaretobedesigned.Therefore,weintroducedsite-specificclickchemistryformakingand purifying robust building blocks for future modular constructs of larger assemblies. Although the present yield of this robust module was only about 10%, it demonstrates a first step toward a general fabrication approach. Interestingly, we find that the click yields follow quantitatively a binomial distribution, the predictability of which indicates the usefulness of preparing pools of pure and robust building blocks in this way. The binomial behavior indicates that there is no interference between the six simultaneous click reactions but that step-yield limiting factors such as topological constraints and Cu(I) catalyst concentration are local and independent." @default.
• W2324391007 created "2016-06-24" @default.
• W2324391007 creator A5004871375 @default.
• W2324391007 creator A5019592288 @default.
• W2324391007 creator A5034838900 @default.
• W2324391007 creator A5074565235 @default.
• W2324391007 creator A5091271050 @default.
• W2324391007 date "2011-01-01" @default.
• W2324391007 modified "2023-09-27" @default.
• W2324391007 title "Nanofabrication Yields. Hybridization and Click-Fixation of Polycyclic DNA" @default.
• W2324391007 cites W1567090568 @default.
• W2324391007 cites W1617520624 @default.
• W2324391007 cites W1656731888 @default.
• W2324391007 cites W1922563352 @default.
• W2324391007 cites W1967863051 @default.
• W2324391007 cites W1968652549 @default.
• W2324391007 cites W1975526910 @default.
• W2324391007 cites W1975679096 @default.
• W2324391007 cites W1983111855 @default.
• W2324391007 cites W1996816533 @default.
• W2324391007 cites W1996881864 @default.
• W2324391007 cites W1998779631 @default.
• W2324391007 cites W1999411237 @default.
• W2324391007 cites W2001303230 @default.
• W2324391007 cites W2006391873 @default.
• W2324391007 cites W2006908644 @default.
• W2324391007 cites W2008686601 @default.
• W2324391007 cites W2013563809 @default.
• W2324391007 cites W2014845274 @default.
• W2324391007 cites W2017558955 @default.
• W2324391007 cites W2023747155 @default.
• W2324391007 cites W2024949907 @default.
• W2324391007 cites W2027838042 @default.
• W2324391007 cites W2040094175 @default.
• W2324391007 cites W2041857964 @default.
• W2324391007 cites W2061937480 @default.
• W2324391007 cites W2061997740 @default.
• W2324391007 cites W2066533320 @default.
• W2324391007 cites W2070744941 @default.
• W2324391007 cites W2078484807 @default.
• W2324391007 cites W2098351335 @default.
• W2324391007 cites W2099737063 @default.
• W2324391007 cites W2103409481 @default.
• W2324391007 cites W2108932098 @default.
• W2324391007 cites W2123281294 @default.
• W2324391007 cites W2126961173 @default.
• W2324391007 cites W2130125491 @default.
• W2324391007 cites W2130508462 @default.
• W2324391007 cites W2145662716 @default.
• W2324391007 cites W2151323671 @default.
• W2324391007 cites W2157446319 @default.
• W2324391007 cites W2164215798 @default.
• W2324391007 cites W2166007193 @default.
• W2324391007 cites W2168584526 @default.
• W2324391007 cites W2903339958 @default.
• W2324391007 hasPublicationYear "2011" @default.
• W2324391007 type Work @default.
• W2324391007 sameAs 2324391007 @default.
• W2324391007 citedByCount "0" @default.
• W2324391007 crossrefType "journal-article" @default.
• W2324391007 hasAuthorship W2324391007A5004871375 @default.
• W2324391007 hasAuthorship W2324391007A5019592288 @default.
• W2324391007 hasAuthorship W2324391007A5034838900 @default.
• W2324391007 hasAuthorship W2324391007A5074565235 @default.
• W2324391007 hasAuthorship W2324391007A5091271050 @default.
• W2324391007 hasConcept C105795698 @default.
• W2324391007 hasConcept C121332964 @default.
• W2324391007 hasConcept C127413603 @default.
• W2324391007 hasConcept C134121241 @default.
• W2324391007 hasConcept C144082473 @default.
• W2324391007 hasConcept C147789679 @default.
• W2324391007 hasConcept C171250308 @default.
• W2324391007 hasConcept C185592680 @default.
• W2324391007 hasConcept C186060115 @default.
• W2324391007 hasConcept C188198153 @default.
• W2324391007 hasConcept C192562407 @default.
• W2324391007 hasConcept C197640229 @default.
• W2324391007 hasConcept C21951064 @default.
• W2324391007 hasConcept C33923547 @default.
• W2324391007 hasConcept C552990157 @default.
• W2324391007 hasConcept C55493867 @default.
• W2324391007 hasConcept C69610077 @default.
• W2324391007 hasConcept C78519656 @default.
• W2324391007 hasConcept C86803240 @default.
• W2324391007 hasConcept C97355855 @default.
• W2324391007 hasConceptScore W2324391007C105795698 @default.
• W2324391007 hasConceptScore W2324391007C121332964 @default.
• W2324391007 hasConceptScore W2324391007C127413603 @default.
• W2324391007 hasConceptScore W2324391007C134121241 @default.
• W2324391007 hasConceptScore W2324391007C144082473 @default.
• W2324391007 hasConceptScore W2324391007C147789679 @default.
• W2324391007 hasConceptScore W2324391007C171250308 @default.
• W2324391007 hasConceptScore W2324391007C185592680 @default.
• W2324391007 hasConceptScore W2324391007C186060115 @default.
• W2324391007 hasConceptScore W2324391007C188198153 @default.
• W2324391007 hasConceptScore W2324391007C192562407 @default.
• W2324391007 hasConceptScore W2324391007C197640229 @default.
• W2324391007 hasConceptScore W2324391007C21951064 @default.
• W2324391007 hasConceptScore W2324391007C33923547 @default.
• W2324391007 hasConceptScore W2324391007C552990157 @default.

• next