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• W2324398051 endingPage "42" @default.
• W2324398051 startingPage "37" @default.
• W2324398051 abstract "In humans, about 1000 enzymes are estimated to bind zinc. In most of these enzymes, zinc is present at the active site; thus, these enzymes are functional as zinc-requiring enzymes. Of these zinc-requiring enzymes, zinc-requiring ectoenzymes (defined as secretory, membrane-bound, and organelle-resident enzymes) have received much attention because of their important physiological functions, involvement in a number of diseases, and potential applications as therapeutic targets for diseases. Zinc-requiring ectoenzymes may become active by coordinating zinc at their active site during the secretory process, which requires elaborate control of zinc mobilization from the extracellular milieu to the cytosol and then lumen in the early secretory pathway. Therefore, zinc transporters should properly maintain the process at systemic, cellular, and subcellular levels by mobilizing zinc across biological membranes. However, few studies have examined the mechanisms underlying this process. In this review, current knowledge of the activation process of zinc-requiring ectoenzymes by ZnT zinc transporters in the early secretory pathway is briefly reviewed at the molecular level, with a focus on tissue-nonspecific alkaline phosphatase. Moreover, we also discuss whether zinc-chaperone proteins function during the activation of these enzymes." @default.
• W2324398051 created "2016-06-24" @default.
• W2324398051 creator A5023576389 @default.
• W2324398051 creator A5070494674 @default.
• W2324398051 creator A5076876397 @default.
• W2324398051 date "2016-12-01" @default.
• W2324398051 modified "2023-09-29" @default.
• W2324398051 title "Activation of zinc-requiring ectoenzymes by ZnT transporters during the secretory process: Biochemical and molecular aspects" @default.
• W2324398051 cites W123484086 @default.
• W2324398051 cites W1509744189 @default.
• W2324398051 cites W1882262859 @default.
• W2324398051 cites W1952065778 @default.
• W2324398051 cites W1964868419 @default.
• W2324398051 cites W1965532980 @default.
• W2324398051 cites W1965891907 @default.
• W2324398051 cites W1969297931 @default.
• W2324398051 cites W1969601086 @default.
• W2324398051 cites W1969994476 @default.
• W2324398051 cites W1971352570 @default.
• W2324398051 cites W1972148783 @default.
• W2324398051 cites W1973364783 @default.
• W2324398051 cites W1979100273 @default.
• W2324398051 cites W1979335914 @default.
• W2324398051 cites W1980107025 @default.
• W2324398051 cites W1982243317 @default.
• W2324398051 cites W1986171863 @default.
• W2324398051 cites W1986894327 @default.
• W2324398051 cites W1989269848 @default.
• W2324398051 cites W1989806335 @default.
• W2324398051 cites W1990830736 @default.
• W2324398051 cites W1993044829 @default.
• W2324398051 cites W1993704013 @default.
• W2324398051 cites W2004471846 @default.
• W2324398051 cites W2017469965 @default.
• W2324398051 cites W2019617999 @default.
• W2324398051 cites W2019828928 @default.
• W2324398051 cites W2022222328 @default.
• W2324398051 cites W2025454110 @default.
• W2324398051 cites W2028347889 @default.
• W2324398051 cites W2029729041 @default.
• W2324398051 cites W2033341544 @default.
• W2324398051 cites W2034752268 @default.
• W2324398051 cites W2036454879 @default.
• W2324398051 cites W2039537470 @default.
• W2324398051 cites W2039859631 @default.
• W2324398051 cites W2043628661 @default.
• W2324398051 cites W2044274518 @default.
• W2324398051 cites W2044772160 @default.
• W2324398051 cites W2045325852 @default.
• W2324398051 cites W2047178318 @default.
• W2324398051 cites W2048356493 @default.
• W2324398051 cites W2054569628 @default.
• W2324398051 cites W2057158848 @default.
• W2324398051 cites W2057370821 @default.
• W2324398051 cites W2060067160 @default.
• W2324398051 cites W2063635739 @default.
• W2324398051 cites W2065442902 @default.
• W2324398051 cites W2066052326 @default.
• W2324398051 cites W2066662117 @default.
• W2324398051 cites W2070228490 @default.
• W2324398051 cites W2078134576 @default.
• W2324398051 cites W2081104776 @default.
• W2324398051 cites W2083615209 @default.
• W2324398051 cites W2088878246 @default.
• W2324398051 cites W2092676399 @default.
• W2324398051 cites W2095745394 @default.
• W2324398051 cites W2102496731 @default.
• W2324398051 cites W2105676752 @default.
• W2324398051 cites W2107007984 @default.
• W2324398051 cites W2109202643 @default.
• W2324398051 cites W2109307088 @default.
• W2324398051 cites W2109609926 @default.
• W2324398051 cites W2110652761 @default.
• W2324398051 cites W2117393206 @default.
• W2324398051 cites W2118480909 @default.
• W2324398051 cites W2124272755 @default.
• W2324398051 cites W2125305082 @default.
• W2324398051 cites W2128687047 @default.
• W2324398051 cites W2130614540 @default.
• W2324398051 cites W2141944872 @default.
• W2324398051 cites W2147519918 @default.
• W2324398051 cites W2157676699 @default.
• W2324398051 cites W2160366016 @default.
• W2324398051 cites W2161175302 @default.
• W2324398051 cites W2164258188 @default.
• W2324398051 cites W2164339857 @default.
• W2324398051 cites W2166617029 @default.
• W2324398051 cites W2169021938 @default.
• W2324398051 cites W2169514498 @default.
• W2324398051 cites W2170056626 @default.
• W2324398051 cites W2305841752 @default.
• W2324398051 cites W45911160 @default.
• W2324398051 doi "https://doi.org/10.1016/j.abb.2016.03.035" @default.
• W2324398051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27046342" @default.
• W2324398051 hasPublicationYear "2016" @default.
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