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• W2324398833 endingPage "e1004651" @default.
• W2324398833 startingPage "e1004651" @default.
• W2324398833 abstract "The advent of high-throughput sequencing techniques has made it possible to follow the genomic evolution of pathogenic bacteria by comparing longitudinally collected bacteria sampled from human hosts. Such studies in the context of chronic airway infections by Pseudomonas aeruginosa in cystic fibrosis (CF) patients have indicated high bacterial population diversity. Such diversity may be driven by hypermutability resulting from DNA mismatch repair system (MRS) deficiency, a common trait evolved by P. aeruginosa strains in CF infections. No studies to date have utilized whole-genome sequencing to investigate within-host population diversity or long-term evolution of mutators in CF airways. We sequenced the genomes of 13 and 14 isolates of P. aeruginosa mutator populations from an Argentinian and a Danish CF patient, respectively. Our collection of isolates spanned 6 and 20 years of patient infection history, respectively. We sequenced 11 isolates from a single sample from each patient to allow in-depth analysis of population diversity. Each patient was infected by clonal populations of bacteria that were dominated by mutators. The in vivo mutation rate of the populations was ∼100 SNPs/year–∼40-fold higher than rates in normo-mutable populations. Comparison of the genomes of 11 isolates from the same sample showed extensive within-patient genomic diversification; the populations were composed of different sub-lineages that had coexisted for many years since the initial colonization of the patient. Analysis of the mutations identified genes that underwent convergent evolution across lineages and sub-lineages, suggesting that the genes were targeted by mutation to optimize pathogenic fitness. Parallel evolution was observed in reduction of overall catabolic capacity of the populations. These findings are useful for understanding the evolution of pathogen populations and identifying new targets for control of chronic infections." @default.
• W2324398833 created "2016-06-24" @default.
• W2324398833 creator A5026916294 @default.
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• W2324398833 creator A5068730771 @default.
• W2324398833 creator A5070791216 @default.
• W2324398833 creator A5088116014 @default.
• W2324398833 date "2014-10-16" @default.
• W2324398833 modified "2023-10-09" @default.
• W2324398833 title "Coexistence and Within-Host Evolution of Diversified Lineages of Hypermutable Pseudomonas aeruginosa in Long-term Cystic Fibrosis Infections" @default.
• W2324398833 cites W1480307447 @default.
• W2324398833 cites W1480808855 @default.
• W2324398833 cites W153704210 @default.
• W2324398833 cites W1550165896 @default.
• W2324398833 cites W1566245339 @default.
• W2324398833 cites W1582758854 @default.
• W2324398833 cites W1680922195 @default.
• W2324398833 cites W1810815273 @default.
• W2324398833 cites W1839159574 @default.
• W2324398833 cites W1842944877 @default.
• W2324398833 cites W1941033876 @default.
• W2324398833 cites W1955612312 @default.
• W2324398833 cites W1966614672 @default.
• W2324398833 cites W1967023708 @default.
• W2324398833 cites W1974365862 @default.
• W2324398833 cites W1979152503 @default.
• W2324398833 cites W1979429534 @default.
• W2324398833 cites W1983165822 @default.
• W2324398833 cites W1984876660 @default.
• W2324398833 cites W1985687704 @default.
• W2324398833 cites W1991601642 @default.
• W2324398833 cites W1992619479 @default.
• W2324398833 cites W2000228858 @default.
• W2324398833 cites W2002201903 @default.
• W2324398833 cites W2010780918 @default.
• W2324398833 cites W2015502647 @default.
• W2324398833 cites W2016711973 @default.
• W2324398833 cites W2021633684 @default.
• W2324398833 cites W2035226835 @default.
• W2324398833 cites W2039554211 @default.
• W2324398833 cites W2043698490 @default.
• W2324398833 cites W2047735187 @default.
• W2324398833 cites W2051970641 @default.
• W2324398833 cites W2062375688 @default.
• W2324398833 cites W2062652176 @default.
• W2324398833 cites W2063156910 @default.
• W2324398833 cites W2069780164 @default.
• W2324398833 cites W2077833306 @default.
• W2324398833 cites W2078848565 @default.
• W2324398833 cites W2080411011 @default.
• W2324398833 cites W2091990251 @default.
• W2324398833 cites W2094013603 @default.
• W2324398833 cites W2095869549 @default.
• W2324398833 cites W2096684565 @default.
• W2324398833 cites W2099439352 @default.
• W2324398833 cites W2100619015 @default.
• W2324398833 cites W2102306849 @default.
• W2324398833 cites W2102614752 @default.
• W2324398833 cites W2102695300 @default.
• W2324398833 cites W2105226320 @default.
• W2324398833 cites W2107282968 @default.
• W2324398833 cites W2108234281 @default.
• W2324398833 cites W2108716844 @default.
• W2324398833 cites W2108862719 @default.
• W2324398833 cites W2109325984 @default.
• W2324398833 cites W2110140401 @default.
• W2324398833 cites W2111247190 @default.
• W2324398833 cites W2113549066 @default.
• W2324398833 cites W2114939043 @default.
• W2324398833 cites W2117064229 @default.
• W2324398833 cites W2117532917 @default.
• W2324398833 cites W2119803749 @default.
• W2324398833 cites W2120655331 @default.
• W2324398833 cites W2120748415 @default.
• W2324398833 cites W2121867408 @default.
• W2324398833 cites W2122923061 @default.
• W2324398833 cites W2122992192 @default.
• W2324398833 cites W2130091893 @default.
• W2324398833 cites W2130362098 @default.
• W2324398833 cites W2136892318 @default.
• W2324398833 cites W2137761651 @default.
• W2324398833 cites W2140059688 @default.
• W2324398833 cites W2141012198 @default.
• W2324398833 cites W2143327185 @default.
• W2324398833 cites W2151724107 @default.
• W2324398833 cites W2160969485 @default.
• W2324398833 cites W2163856333 @default.
• W2324398833 cites W2165913026 @default.
• W2324398833 cites W2165928400 @default.
• W2324398833 cites W2166135736 @default.
• W2324398833 cites W2167414706 @default.
• W2324398833 cites W2168133698 @default.
• W2324398833 cites W2169053394 @default.
• W2324398833 cites W2169846007 @default.
• W2324398833 cites W2170382524 @default.

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