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• W2324521738 endingPage "147" @default.
• W2324521738 startingPage "136" @default.
• W2324521738 abstract "Bipolar disorder (BPD) is genetically heterogeneous with a growing list of BPD associated genes reported in recent years resulting from increased genetic testing using advanced genetic technology, expanded genomic databases, and better awareness of the disorder. We compiled a master list of recognized susceptibility and genes associated with BPD identified from peer-reviewed medical literature sources using PubMed and by searching online databases, such as OMIM. Searched keywords were related to bipolar disorder and genetics. Our compiled list consisted of 290 genes with gene names arranged in alphabetical order in tabular form with source documents and their chromosome location and gene symbols plotted on high-resolution human chromosome ideograms. The identified genes impacted a broad range of biological pathways and processes including cellular signaling pathways particularly cAMP and calcium (e.g., CACNA1C, CAMK2A, CAMK2D, ADCY1, ADCY2); glutamatergic (e.g., GRIK1, GRM3, GRM7), dopaminergic (e.g., DRD2, DRD4, COMT, MAOA) and serotonergic (e.g., HTR1A, HTR2A, HTR3B) neurotransmission; molecular transporters (e.g., SLC39A3, SLC6A3, SLC8A1); and neuronal growth (e.g., BDNF, IGFBP1, NRG1, NRG3). The increasing prevalence of BPD calls for better understanding of the genetic etiology of this disorder and associations between the observed BPD phenotype and genes. Visual representation of genes for bipolar disorder becomes a tool enabling clinical and laboratory geneticists, genetic counselors, and other health care providers and researchers easy access to the location and distribution of currently recognized BPD associated genes. Our study may also help inform diagnosis and advance treatment developments for those affected with this disorder and improve genetic counseling for families." @default.
• W2324521738 created "2016-06-24" @default.
• W2324521738 creator A5006158450 @default.
• W2324521738 creator A5034859850 @default.
• W2324521738 creator A5045905377 @default.
• W2324521738 creator A5084146223 @default.
• W2324521738 date "2016-07-01" @default.
• W2324521738 modified "2023-09-27" @default.
• W2324521738 title "High-resolution chromosome ideogram representation of recognized genes for bipolar disorder" @default.
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• W2324521738 doi "https://doi.org/10.1016/j.gene.2016.04.011" @default.
• W2324521738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6675571" @default.
• W2324521738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27063557" @default.
• W2324521738 hasPublicationYear "2016" @default.
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