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- W2324558064 abstract "The regulation of genome architecture is essential for a variety of fundamental cellular phenomena that underlie the complex orchestration of mammalian development. The ATP-dependent chromatin remodeling protein ATRX is emerging as a key regulatory component of nucleosomal dynamics and higher order chromatin conformation. Here we provide an overview of the role of ATRX at chromatin and during development, and discuss recent studies exposing a repertoire of ATRX functions at heterochromatin, in gene regulation, and during mitosis and meiosis. Exciting new progress on several fronts suggest that ATRX operates in histone variant deposition and in the modulation of higher order chromatin structure. Not surprisingly, dysfunction or absence of ATRX protein has devastating consequences on embryonic development and leads to human disease." @default.
- W2324558064 created "2016-06-24" @default.
- W2324558064 creator A5047120336 @default.
- W2324558064 date "2011-10-01" @default.
- W2324558064 modified "2023-09-26" @default.
- W2324558064 title "ATRX in chromatin assembly and genome architecture during development and disease" @default.
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- W2324558064 doi "https://doi.org/10.1139/o11-038" @default.
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